缓解期双相情感障碍患者及其近亲属和正常人群认知功能对照研究

Comparative study of cognitive function in patients with bipolar affective disorder in remission period and their close relatives and normal population

目的比较双相情感障碍患者缓解期认知功能与其近亲属和正常人群的认知功能。方法选取我院2015年1月~2016年6月的50例缓解期双相情感障碍Ⅰ型患者作为研究1组,50例缓解期双相情感障碍Ⅱ型患者作为研究2组,抽取两研究组的50名健康近亲属作为亲属组及50名正常人群作为对照组进行研究,分别采用数字符号、连线测验A(TMT-A)时间、连线测验B(TMT-B)时间、数字广度(顺背、倒背、总分)和威斯康星卡片分类测验(WCST)评定接受测试者,比较各组的注意力、记忆功能和执行功能。结果研究1组和2组的TMT-A时间、TMT-B时间、数字广度(顺)高于亲属组和对照组,差异有统计学意义(P<0.05)。研究1组的TMT-A时间、TMT-B时间长于研究2组,差异有统计学意义(P<0.05)。研究1组和2组的数字广度(倒)、数字广度总分显著低于亲属组和对照组,差异有统计学意义(P<0.05)。对照组的数字符号值显著高于其他三组,差异有统计学意义(P<0.05)。研究1组、研究2组及亲属组WSCT的非持续性错误数、错误应答数显著高于对照组,差异有统计学意义(P<0.05)。研究1组、亲属组WSCT的非持续性错误数、错误应答数显著高于研究2组,差异有统计学意义(P<0.05)。研究1组和亲属组的完成分类数、不能维持完整分类数、完成第1个分类所需应答数、总应答数与研究2组、对照组比较,差异有统计学意义(P<0.05)。结论缓解期双相情感障碍Ⅰ型、Ⅱ型患者及其近亲属存在认知功能损害,Ⅰ型患者执行力损害较明显,Ⅱ型患者注意力较Ⅰ型损害明显。

Objective To compare the cognitive function between patients with bipolar affective disorder in remission period and its close relatives and normal population.Methods 50 cases of bipolar affective disorder type I patients in remission period in our hospital from January 2015 to June 2016 were selected as the study group 1,50 cases of bipolar affective disorder type Ⅱ patients in remission period were selected as the study group 2,50 cases healthy close relatives from two study groups were selected as the relatives group and 50 normal subjects were selected as the control group.All the subjects were assessed respectively by the digit symbol,trail making test A （TMT-A） time,trail making test B （TMT-B） time,digital breadth （forward,backward,total score） and Wisconsin card sorting test （WCST）,and the attention,memory and executive function of each group were compared.Results The TMT-A time,TMT-B time and digital breadth （forward） of the study group 1 and the study group 2 were higher than those in the relatives group and the control group,with significant difference （P〈0.05）.The TMT-A time and TMT-B time of the study group 1 were longer than those of the study group 2,with significant difference （P〈0.05）.The digital breadth （backward） and the total digital breadth score of the study group 1 and the study group 2 were significantly lower than those in the relatives group and the control group,with significant difference （P〈0.05）.The number of digital symbols in the control group was significantly higher than that in the other three groups,with significant difference （P〈0.05）.The non-persistent error number,error responses of WSCT in the study group 1,the study group 2 and the relatives group were significantly higher than that in the control group,with significant difference （P〈0.05）.The non-persistent error number,error responses of WSCT in the study group 1 and the relatives group were significantly higher than that in the study group 2,with significant difference （P〈0.05）.There was significant difference in the complete classification number,non-maintaining complete classification number and the number of responses required to complete the first classification and the number of total responses between the study group 1,the relatives group and the study group 2,the control group （P〈0.05）.Conclusion There are many cognitive impairment in patients with type Ⅰ and type Ⅱ in remission stage and their close relatives,and the damage of executive power in type Ⅰ patients is more obvious,the damage of attention in type Ⅱ patients is more obvious than that in type I patients.