1,6-二羟基-2-萘甲酸的合成研究

Synthesis of 1,6-Dihydroxy-2-naphthoic Acid

标题化合物是合成新型内分泌治疗剂的重要中间体,而其合成方法未见文献报道。以6-甲氧基-1-萘满酮为起始原料,经取代、氧化和水解3步反应得到目标产物,其结构经MS、~1HNMR、^(13)CNMR和IR确证。该路线原料廉价易得、操作简单、后处理方便,总收率达69.5%,适合工业化生产。

1,6-Dihydroxy-2-naphthoic acid is an important intermediate for the synthesis of new endocrine the rapy medicine.In this work,6-methoxy-1-tetralone was used as the starting material.The target product was obtained by three steps of substitution,oxidation and hydrolysis.The structures were confirmed by MS,^1HNMR,^13CNMR and IR.The raw material of this route is cheap and easy to obtain,and the optimized process is simple in operation,short in reaction time and easy to purify.The total yield reaches 69.5%,which is suitable for industrial production.