摘要
以间甲氧基苯胺和乙氧基亚甲基丙二酸二乙酯(EMME)为起始原料,经缩合、Gould-Jacobs高温环合、水解、脱羧、硝化反应合成标题化合物,总收率达48.74%,其结构经ESI-MS、~1HNMR和IR确证。
4-Hydroxy-7-methoxy-8-nitroquinoline in overall yield of 48.74% was synthesized from 3-methoxy aniline by a five-step reaction of condensation,Gould-Jacobs cyclization,hydrolysis,decarboxylation and nitration.The structure was confirmed by ESIMS,^1HNMR and IR.
出处
《化学试剂》
北大核心
2017年第7期785-786,789,共3页
Chemical Reagents
基金
辽宁省自然科学基金资助项目(201520695)
