结直肠癌腹膜转移的发病和诊疗进展

Research Progress in the Pathogenesis,Diagnosis and Treatment of Colorectal Cancer Peritoneal Metastasis

结直肠癌腹膜转移的发病是肿瘤细胞与腹膜在黏附因子和相关介质的参与下,相互作用和特异性选择的结果。大网膜上丰富的乳斑结构使其成为此类疾病的好发位点。现阶段结直肠癌腹膜转移的诊断、术式的选择、药物的应用已逐渐趋于标准化;肿瘤细胞减灭术和腹腔内温热化疗的联合应用以及治疗对象的合理选择,有效地改善了患者的生存预后。而腹腔内温热化疗协同作用的疗效以及结直肠癌大网膜转移的应对策略将会是未来研究的重点。

The pathogenesis of colorectal cancer peritoneal metastasis is the result of the interaction and specific selection of tumor cells and peritoneum with the involvement of adhesion factors and related mediators. The rich milky spots on the omentum make it a good site for such diseases. At present, the diagnosis, surgical choice and the drug application of such diseases have gradually become standardized. The application of combined cytoreductive surgery and hypeermic intraper- itoneal chemotherapy, and reasonable treatment object selection have effectively improved the survival prognosis of patients. And the effect of hyperthermic intraperitoneal chemotherapy and the countermeasure for colorectal cancer omentum metasta- sis will be the focus of the future research.