三维彩色多普勒超声定量血流分析在早期宫颈癌筛查诊断中的应用

The application of quantitative analysis of blood flow by using three-dimensional color Doppler ultrasound in the diagnosis of early screening diagnosis of cervical cancer

目的探讨三维彩色多普勒超声定量血流分析在早期宫颈癌筛查诊断中的临床价值。方法选择早期宫颈癌患者60例为观察组,同时选择宫颈细胞学检查正常者60例为对照组。均行三维彩色多普勒超声定量血流分析,比较两组血流参数血管形成指数(VI)、血流指数(FI)、血管化血流指数(VFI)。结果观察组49例肿块内血管丰富,走形杂乱,其丰富的彩色血流呈"火球"状或网状,11例宫颈局部血流较丰富,三维成像后可见数支条状或"短棒"状血管,但无"火球"状表现;对照组宫颈仅显示宫颈内无或少许血流信号。两组VI、FI、VFI值随病变严重程度呈上升趋势,其宫颈血流信号随着宫颈病变升为恶性而明显增强,观察组定量血流分析参数值VI、FI、VFI均显著高于正常对照组,差异有统计学意义(P<0.05)。结论三维彩色多普勒超声定量血流分析参数VI、FI、VFI可提供宫颈肿块内血流情况,评估早期宫颈癌肿瘤血管生成,了解局部血供特点及血管生成状况,为早期宫颈癌的筛查诊断提供了重要诊断信息。

Objective o explore the clinical value of quantitative analysis of blood flow in cervical tissue by using three-di- mensional color Doppler flow image （CDFI） in early screening diagnosis of cervical cancer. Methods We randomly selected 60 pa- tients with early cervical cancer as an observation group, and 60 healthy subjects confirmed by cervical cytology as a control group. All participants had the CDFI and vascular formation index （VI） ,blood flow index （FI） and vascular blood flow index （VFI） were com- pared between the two groups. Results In the observation group,49 cases showed rich blood vessels in tumor,which were contorts of clutter presenting as ＂fireball＂ shape or mesh. The rest 11 cancer patients showed abundant blood flow in cervix which presented as strip or ＂short＂ veins,but no ＂fireball＂ performance. In the control group,there was only little or blood flow signals in the cervix. The values of VI, FI and VFI were increased with severity of lesions in the both groups, especially when cervical lesions were transferred to malignant one. The values of VI, FI and VFI in the observation group were significantly higher than those in the control group （ P 〈 0.05 ）. Conclusion The blood flow parameters of VI, FI and VFI of CDFI can provide the blood flow status in cervical mass, estimate tumor angiogenesis and evaluate the characteristics of the local blood supply and angiogenesis status. These will provide the important information for early screening diagnosis of the cancer.