摘要
建立了一种简捷、绿色合成多取代色酮并双环吡啶类化合物的合成方法.该方法是利用色酮-3-甲醛1与N-苄基硝基烯酮缩胺(NBNKAs,2)在乙醇中反应,一步合成色酮并双环吡啶化合物.通过直接抽滤得目标产物3,无需额外的后处理操作.该方法具有合成成本低,反应溶剂生物相容性好,反应条件温和,原子经济性,高产率(93~98%)及产物具有潜在的生物活性等显著优势.
A concise and environment friendly route for the synthesis of multisubstituted chromone-fused bicyclic pyridine compounds via one-step reaction of chromone-3-carboxaldehyde 1 and N-benzyl nitro ketene aminals（NBNKAs, 2） in ethanol media has been developed. The targeted compounds 3 can efficiently obtain by filter without extra post-treatment. The reaction is particularly attractive due to following features： low-cost and biocompatibility solvent, mild temperature, atom economy, high yields, and potential biological activity.
出处
《有机化学》
SCIE
CAS
CSCD
北大核心
2017年第6期1433-1442,共10页
Chinese Journal of Organic Chemistry
基金
国家自然科学基金(Nos.U1202221
21362042
21262042
21662042)
云南省后备人才(No.2012HB001)
云南大学青年英才计划(No.XT412003)资助项目~~
关键词
环境友好
原子经济
无催化剂
咪唑并吡啶
新烟碱类
environment friendly
atom economy
catalyst-free
bicyclic pyridine
neonicotinoids
