聚乙二醇单甲醚修饰蒽化合物纯水相荧光识别Hg^(2+)及半胱氨酸

A New Methoxy Poly (ethylene glycol)-anchored Anthracene for Fluorescence Sensing of Hg^(2+) and Subsequent of Cysteine in Pure Aqueous Solution

通过点击反应合成了一种聚乙二醇单甲醚(mPEG)修饰含蒽荧光团及二(2-吡啶甲基)胺(DPA)金属离子识别位点水溶性高分子化合物P1.在纯水溶液中,P1能够与Hg^(2+)形成稳定的1∶1型配合物P1-Hg^(2+),伴随着聚合物P1荧光猝灭.同时,P1-Hg^(2+)络合物对半胱氨酸(Cys)有很好的选择性识别.随着Cys浓度的增加,由于Cys与Hg^(2+)结合,使得P1的荧光得到恢复,且不受其它氨基酸的干扰.

A new Methoxy poly（ethylene glycol）-anchored polymer sensor P1, which contains anthracene fluorephore and di-2-picolylamine metal ions binding site, has been easily synthesized by ＂click reaction＂. In pure aqueous solution, P1 can coordinate with Hg^（2＋） quickly to form 1∶1 stoichiometry P1-Hg^（2＋） complex, with quenching the fluorescence of P1. In addition, P1-Hg^（2＋） shows exclusive fluorescence turn-on sensing of cysteine（Cys） over other amino acids for the displacement method.