聚乙二醇干扰素α-2a治疗不同中医证型慢性乙型肝炎的疗效分析

Relationship between traditional Chinese medicine syndrome of chronic hepatitis B and antiviral curative effect by pegylated interferon-2a

目的:观察慢性乙型肝炎中医证型与聚乙二醇干扰素α-2a抗病毒疗效的关系。方法:入选符合抗病毒治疗指征的慢性乙型肝炎患者98例,按中医辨证分湿热中阻型、肝郁脾虚型、肝肾阴虚型、脾肾阳虚型、瘀血阻络型。各型患者均使用聚乙二醇干扰素α-2a治疗48周,观察聚乙二醇干扰素α-2a对不同中医证型HBV DNA的转阴率、HBe Ag血清转换率以及HBs Ag阴转率与中医证型之间的关系。结果:湿热中阻型HBV DNA的转阴率、HBe Ag血清转换率及HBs Ag阴转率最高,分别为54.5%、30.3%、12.1%,与其他证型比较差异有统计学意义。结论:聚乙二醇干扰素α-2a治疗慢性乙型肝炎的疗效与中医证型相关。

Objective： To study the relationship between the traditional chinese medicine （TCM） syndrome of chronic hepatitis B （ CHB ） and the antiviral curative effect by pegylated interferon -2a （PEG-IFN -2a） . Methods： Ninety-eight patients of CHB were divided into five groups by TCM syndrome,which were dampheat blocking the middle group, depressed liver and deficient spleen group, Yin deficiency of liver and kidney group, Yang deficiency of spleen and kidney group and blood stasis blocking collaterals group . The patients were received PEG-IFN -2a for 48 weeks. The relationship between the rate of the negativity HBV DNA and HBeAg seroconversion and HBsAg clearance of different TCM syndrome were investigated. Results： The highest negativity rate of HBV DNA and HBeAg seroconversion and HBsAg clearance were in dampheat blocking the middle group , result was 54.5% and 30.3% and 12.1%, comparison with other TCM syndrome with statistical significance. Conclusion： The antiviral curative effect and pegylated interferon -2a treatment in patients with CHB is closely correlated with TCM syndrome.