血清胸苷激酶1的检测在非小细胞肺癌诊断及疗效评估中的意义

Significance of Detection of Serum Thymidine Kinase 1 in Diagnosis and Curative Effect Evaluation of Non-small Cell Lung Cancer

目的:分析血清胸苷激酶1(STK1)的检测在非小细胞肺癌诊断及疗效评估中的意义。方法:选择我院及同济医院2014年5月~2015年5月收治的非小细胞肺癌患者60例,设置为a组,另同期选择健康体检者60例,设置为b组,对比两组受检者的血清STK1水平。结果:a组受检者术前的血清STK1水平相比b组明显较高,术后1个月的血清STK1水平明显低于术前,P<0.05;疾病复发9例,未复发39例,复发患者手术治疗后随访12个月的血清STK1水平明显高于未复发的血清STK1水平,P<0.05;鳞癌的血清STK1水平明显高于腺癌,P<0.05。结论:对非小细胞肺癌患者来说,检测血清STK1水平的临床意义重大,有利于疾病的诊断、治疗与预后的评估。

Objective：Objective to analyze the serum of thymidine kinase 1 （STK1） detection in lung cancer diagnosis and curative effect evaluation of significance.Methods：From May 2014 to May 2015 were 60 patients with Fung cancer,set to group a,the other at the same time choose 60 cases of healthy check-up,set to group b,compared two groups of subjects of blood serum STK1 level.Results：Patients in group a preoperative blood serum STK1 level significantly higher than group b,after 1 month of blood serum STK1 level significantly lower than the preoperative.P 〈 0.05;Relapse 9 cases,39 cases of recurrence,patients with recurrence after surgery were followed up for 12 months of blood serum STK1 level obviously higher than that of without recurrence of blood serum STK1 level,P 〈 0.05;Squamous cell carcinomas of the blood serum STK1 level obviously higher than that of adenocarciooma,P 〈 0.05）.Conclusion：For patients with lung cancer,clinical detection of blood serum STK1 level is of great significance,is conducive to disease diagnosis,treatment and prognosis assessment.