摘要
前列腺素类E2(prostaglandin E2,PGE2)是一种重要的脂质代谢产物,它参与调节多种生理和病理过程,包括炎性疼痛.研究PGE2在疼痛中所起到的作用及其机制有利于阐明痛觉生理和发现疼痛治疗的新手段.目前研究表明,PGE2在中枢可以通过EP受体引起神经递质谷氨酸等的释放,从而导致中枢敏感化;在外周参与伤害性感受器的活化,促进伤害性信息的传递.PGE2及其受体可以作为开发镇痛药物的新靶点.
Prostaglandin E2（PGE2） is an important lipid metabolite of arachidonic acid and involved in modulating physiolo-gical and pathological process including imflammatory pain. The study of the effect and mechanism of PGE2 can help to elucidate physiology of inflammatory pain and discover the clinical therapy. In the central, PGE2 can induce the release of neurotransmitter glutamate etc. through EP receptor and lead to central sensitization; In the peripheral, PGE2 can active the nociceptor and advance the nociceptive information transmission. PGE2 and EP receptors can be researched as a new target in exploring antinociceptive medication.
出处
《闽南师范大学学报（自然科学版）》
2017年第2期65-70,共6页
Journal of Minnan Normal University：Natural Science
基金
福建省自然科学基金项目(2015J01144)
