p53和survivin蛋白水平在宫内膜异位症相关性卵巢癌组织中的表达意义研究

The study of expression and significance of p53 and survivin protein levels in ovarian cancer tissue of endometriosis

目的研究p53和survivin蛋白水平在宫内膜异位症相关性卵巢癌组织中的表达意义。方法选取2013年2月到2015年10月期间接诊的40例子宫内膜异位症相关性卵巢癌患者作为研究组,再选取40名健康人群作为对照组。两组均进行常规检查,然后检测并记录两组患者的p53和survivin蛋白表达阳性率、卵巢癌组患者中不同病理类型p53和survivin蛋白表达PI值、不同临床分期p53和survivin蛋白表达PI值以及不同病理分级p53和survivin蛋白表达PI值并对其结果进行比较分析。结果研究组的p53阳性率以及survivin阳性率分别为65.0%和45.0%,而对照组的p53阳性率以及survivin阳性率均为0,差异具有统计学意义(P<0.05)。对于卵巢癌患者,其不同的病理类型p53和survivin蛋白表达PI值均无显著差异(P>0.05)。卵巢癌组中不同临床分期以及不同病理分级的p53和survivin蛋白表达PI值均明显高于对照组患者,差异具有统计学意义(P<0.05),且在卵巢癌组中,随着临床分期的增加,其p53和survivin蛋白表达PI值也在逐渐增加,且各分期中p53和survivin蛋白表达PI值均有显著差异(P<0.05)。随着病理分级的增加,其p53和survivin蛋白表达PI值也在逐渐增加,且各分级中p53和survivin蛋白表达PI值均有显著差异(P<0.05)。结论子宫内膜异位症相关性卵巢癌患者的p53和survivin蛋白表达阳性率均有明显的升高,且p53和survivin蛋白表达PI值受不同临床分期以及不同病理分级的影响。

Objective To study the expression of p53 and survivin protein levels in ovarian cancer tissue of endometriosis.Methods 40 cases of endometriosis associated ovarian cancer patients from 2013 February to October 2015 during admissions were selected as study group, 40 cases of normal patients as control group.Two groups were performed routine examination and treatment.The p53 and survivin protein positive expression rate, the PI value of p53 and survivin protein in ovarian cancer patients with different pathological types, the PI value of p53 and survivin protein in ovarian cancer patients with different clinical staging and different pathological grading were detected, recorded and compared.Results The p53 positive rate and survivin positive rate of the study group were 65% and 45% respectively, while the p53 positive rate and survivin positive rate in the control group were 0, and the difference was statistically significant （P〈0.05）.For patients with ovarian cancer, pathological types of p53 and survivin protein expression in two groups were not significantly different （P〉0.05）.The study group in different clinical staging and different pathological grading of p53 and survivin protein expression pI value were significantly higher than those in the control group, the difference was statistically significant （P〈0.05）, with the increase of clinical staging, p53 protein, and survivin table of PI value also increased gradually, and each stage p53 and survivin protein expression of PI had significant differences （P〈 0.05）.With the increase of pathological grade, the expression of PI and survivin protein were gradually increased, and the expression of PI and survivin protein in each grade were significantly different （P〈0.05）.Conclusion p53 and survivin protein expression positive rate are significantly higher in uterine endometriosis associated ovarian cancer patients.p53 protein and survivin expression of PI values are not influenced by different clinical stages and different pathological grading.