子痫前期蛋白尿程度与围产期结局的关系:高危妊娠的回顾性分析

Relationship between the degree of proteinuria in preeclampsia and perinatal outcomes: a retrospective analysis of high risk pregnancy

目的研究子痫前期尿蛋白程度与围产期母儿结局的关系。方法以2015年1月至2016年12月分娩的子痫前期患者120例作为实验组,并选取110例正常孕妇作为对照组。按24 h尿蛋白定量将实验组分为轻度尿蛋白组、中度尿蛋白组、重度尿蛋白组,比较四组围产期母儿结局。结果中重度尿蛋白组孕产妇胎盘早剥、急性心力衰竭的发病率和剖宫产率较轻度尿蛋白组和对照组增高(P<0.05),且围产儿体重及胎儿窘迫、胎儿生长受限、新生儿疾病的发病率也较高(P<0.05);随着尿蛋白的增加,重度尿蛋白组患者孕产妇的急性肺水肿和急性肾功能衰竭的发病率增加(P<0.05),围产儿的新生儿窒息发病率也增加(P<0.05)。结论子痫前期患者尿蛋白的程度与围产期母儿结局病情密切相关,尿蛋白越高,围产期结局越差。

Objective To study the relationship between the degree of proteinuria in preeclampsia and perinatal outcome.Methods From January 2015 to December 2016, 120 cases of patients with preeclampsia were selected as experimental group, 110 normal pregnant women as control group.According to 24 h urinary protein in the experimental group were divided into mild proteinuria group, moderate proteinuria group, severe proteinuria group, compared four groups of perinatal outcomes.Results Maternal placental abruption, acute heart failure and the incidence of cesarean section in moderate proteinuria group were higher than those in mild proteinuria group and control group （P〈0.05）, body weight and fetal distress in fetus, fetal growth restriction, the incidence of neonatal disease were also higher （P〈0.05）.With the increase of urinary protein, the incidence of acute pulmonary edema and acute renal failure in pregnant women with severe proteinuria increased （P〈0.05）.The incidence of neonatal asphyxia was also increased （P〈0.05）.Conclusion The degree of proteinuria in preeclampsia is closely related to the perinatal outcome.The higher the urine protein, the worse the perinatal outcome.