冠心病患者血清三酰甘油脂肪酶与炎性因子水平的相关性研究

Relationship between serum ATGL and inflammatory factors in patients with coronary heart disease

目的探讨冠状动脉粥样硬化性心脏病(CHD)患者血清三酰甘油脂肪酶(ATGL)与炎性因子的关系。方法选择CHD患者135例,健康对照者50例,依据相关诊断标准将CHD患者分为稳定性心绞痛(SAP)组(53例)、不稳定性心绞痛(UAP)组(46例)、急性心肌梗死(AMI)组(36例)。采用ELISA法测定血清ATGL、肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-10(IL-10)、1,25二羟维生素D3[1,25(OH)2D3],并做统计学处理。结果 CHD组ATGL、1,25(OH)2D3水平低于健康对照组,TNF-α、IL-6、IL-10水平高于对照组(P<0.05)。按临床类型分组:AMI组ATGL、1,25(OH)2D3水平明显低于SAP组和UAP组,TNF-α、IL-6、IL-10水平高于SAP组、UAP组(P<0.05);UAP组ATGL、1,25(OH)2D3水平低于SAP组,TNF-α、IL-10高于SAP组(P<0.05)。Spearman相关分析显示,在CHD组血清ATGL水平与TG、LDL-C、LP(a)、TNF-α、IL-6、IL-10呈负相关(r=-0.289、-0.227、-0.359、-0.243、-0.205、-0.337,P<0.05),与年龄、HDL-C、1,25(OH)2D3呈正相关(r=0.267、0.356、0.229,P<0.05)。结论 CHD患者ATGL含量随炎症因子升高而下降,在CHD进展中发挥一定的抗炎作用,可以作为提示CHD病情变化的监测指标之一。

Objective To investigate the relationship between serum three triacylglycerol lipase(ATGL)and inflammatory factors in patients with coronary atherosclerotic heart disease(CHD).Methods 135 cases of CHD patients,and 50 healthy people were enrolled in the study.CHD patients were divided into stable angina pectoris(SAP)group(53cases),unstable angina pectoris(UAP)group(46cases)and acute myocardial infarction(AMI)group(36cases)according to relevant diagnostic criteria.The serum levels of ATGL,tumor necrosis factor(TNF-α),interleukin-6(IL-6),interleukin-10(IL-10),1,25 dihydroxy vitamin D3[1,25(OH)2D3]were measured by ELISA,and statistical treatment was performed.Results The levels of ATGL,1,25(OH)_2D_3 in CHD group were lower than that in control group,and the levels of TNF-α,IL-6and IL-10 were higher than those of control group(P<0.05).Comparison among different clinical types of CHD patients showed that ATGL,1,25(OH)_2D_3 levels of AMI group were significantly lower than those of SAP group and UAP group,while TNF-α,IL-6and IL-10 were higher than those of SAP group and UAP group(P<0.05);the levels of ATGL,1,25(OH)_2D_3 in UAP group were lower than those in SAP group,and TNF-αand IL-10 were higher than those in SAP group(P<0.05).Spearman correlation analysis showed that in the CHD group the serum levels of ATGL negatively correlated with TG,LDL-C,LP(a),TNF-α,IL-6,IL-10(r=-0.289,-0.227,-0.359,-0.243,-0.205,-0.337,P<0.05),while positively correlated with age,HDL-C,1,25(OH)2D3(r=0.267,0.356,0.229,P<0.05).Conclusion The ATGL levels in patients with CHD decreases with the increase of inflammatory factors,and plays a certain anti-inflammatory role in the progression of CHD.It can be used as a monitoring indicator to reflex the progress of CHD.