自体外周血干细胞移植和自体骨髓移植治疗恶性血液病造血重建与并发症的比较

Comparison of hematologic reconstitution and complication between aut ologous peripheral blood stem cell a nd autologous bone marrow trasplantation in the tr eatment of malignant hematological diseases

目的评价自体外周血干细胞移植(APBSCT)与自体骨髓移植(ABMT)治疗恶性血液病造血重建和并发症。方法用ABMT治疗21例,用APBSCT治疗25例。预处理方案包括全身照射(TBI)加环磷酰胺(CTX)或TBI加全淋巴结照射(TLI)加CTX加Vp16或MAC方案,结果ABMT组造血重建19例,相关死亡2例,1例感染死亡,1例脑出血死亡,两年无病生存率(DFS)68.50%±10.87%;而PBSCT25例均获造血重建,无移植相关死亡。两年DFS为62.34%±14.26%。两组差异无显著意义。结论ABMT疗效与APBSCT相当,但ABMT骨髓造血重建较APBSCT慢,相关死亡率增加。

Objective To evaluate the hematologic reconstitution and complication between of autologous peripheral blood stem cell tansplantation(ABMT )in the treatment of malignant hemato logical.Methods Twenty-one patients received ABMT and twenty-five patients received APBSCT.The conditioning regime n were total body irradiation(TBI )and CTX or TBI with total lymphoid irradiation(TLI )and CTX and Vp16or MAC regimen.Results Twenty-one patients in ABMT and all patients in APBSCT the 2-years probabilities of disease free survival(DFS)were 68.5%±10.87%and 62.34%±14.26%respectively.Conclusions The clinical efficacy of APBSCT was s imilar to ABMT.Related death of ABMT was higher than APBSCT.[