可逆交联聚电解质微胶囊的制备及表征

Preparation and Characterization of Reversible Crosslinked Polyelectrolyte Microcapsules

微胶囊在医药、食品、化妆品、日用品等行业都有重要应用,其中作为缓释载体的智能降解型微胶囊受到人们越来越多的关注。以MnCO3微粒为模板,采用聚烯丙基胺盐酸盐(PAH)作为壁材,通过层层自组装(LBL)方法得到二硫键交联的聚电解质微胶囊,并对该微胶囊的形貌和化学结构进行了表征分析。结果表明:制备得到微胶囊粒径分布均匀,大小在2.40μm左右,壁厚约为55.25nm;具有一定的机械强度,在高浓度的聚苯乙烯磺酸钠(PSS)溶液中会发生可逆弹性形变;傅里叶红外光谱显示,PAH中的部分氨基已经与交联剂3,3′-二硫代二丙酸(DPA)中的羧基在EDC/NHS存在的条件下发生了交联反应,从而形成了比较稳定的囊壁结构。

Microc ap su les have been widely used ／n m e d ic in e , fo o d , cosme tics and daily necessities. E s pecial ly,the smar t degradable microcapsules which served as car r ier s for control led releas e of d ru g s , DNA,RNA and proteins have got more and more attent ion s . In th is p a p e r, a novell inking degradable polyelectrolyte microcapsule was prepared via layer -by- layer （LBL） method. MnCO3 micropar t icles and 3 , 3 ’-D i th io d ip ro p io n ic acid （DP A） w ere employed as tem p la te s and wall ma te r ia ls , re s pectively. The resul ts s how th a t th e m icro capsu les have u niform s h a p e ： th e size is ap ji m while the wall thicknes s is 55. 25 nm. The SEM and AFM resul ts s how th a t th e m icro capsu les have mechanical st rength to some extent and occurred reversible deformation. The FTIR resul ts also indicate that the amino groups of PAH can par t ial ly cro s s -l in k w i th carb o x y g ro u p s of DPA in th e presen ce of EDC/NHS leading to th e fo rma t io n of s ta b le wa l ls of micro capsu les.