内源性库欣综合征患者脉络膜大血管层高速血流密度的扫频光源光相干断层扫描血流成像分析

The fast blood flow density of intermediate choroid in endogenous Cushing syndrome： analysis of optical coherence tomography angiography

目的对比观察内源性库欣综合征（ECS）患者与健康人脉络膜大血管层高速血流密度（FBFD）的差异。方法住院并确诊的连续ECS患者7例13只眼（ECS组）和年龄、性别、眼轴长度匹配的健康志愿者7名13只眼（对照组）纳入研究。采用扫频光源光相干断层扫描（SS-OCT）对黄斑区进行放射线扫描并测量中心凹下脉络膜厚度（SCT）；采用扫频光源光相干断层扫描血管成像（SS-OCTA）对黄斑区进行3.0 mm×3.0 mm扫描，截取Bruch膜与脉络膜巩膜交界面之间1/2脉络膜厚度所在层面的SS-OCTA图像，所得灰度图经二值化处理转换为黑白图，计算脉络膜大血管层FBFD。结果ECS组、对照组受检者SCT分别为（394.7±77.7）、（332.1±68.1）μm；脉络膜大血管层FBFD分别为（76.35±14.46）%、（63.57±13.42）%。两组受检者SCT（t=2.923）、脉络膜大血管层FBFD（t=2.775）比较，差异均有统计学意义（P=0.008、0.010）。结论ECS患者脉络膜大血管层FBFD显著高于健康对照者。

ObjectiveTo compare the fast blood flow density （FBFD） of intermediate choroid between endogenous Cushing syndrome （ECS） patients and healthy control subjects.MethodsThirteen eyes of 7 eligible ECS patients （ECS group） and 13 eyes of 7 gender, age, axial length matched healthy volunteers （control group） were enrolled in this study. For each subject, macular radial scan with swept source optical coherence tomography （SS-OCT） was performed and subfoveal choroidal thickness （SCT） was measured. Then 3.0 mm×3.0 mm macular scan with SS-OCT angiography was performed, and selected blood flow image at intermediate choroid level or 1/2 SCT beneath Bruch membrane. The grayscale images were then binarized for the analysis of FBFD.ResultsThe SCT in ECS group was （394.7±77.7） μm, which was significantly thicker than （332.1±68.1） μm in control group （t=2.923, P=0.008）. The FBFD of intermediate choroid in ECS group were （76.35±14.46）%, which were significantly greater than （63.57±13.42）% in control group （t=2.775, P=0.01）.ConclusionECS patients had increased FBFD at intermediate choroid level compared with healthy controls.