摘要
基于"炎癌链学说"提出中医"邪毒致变"观点,认为据此探讨幽门螺杆菌(helicobacter pylori,Hp)感染与炎症因子、微小核糖核酸(microRNA)基因多态性微效作用累积效应的差异,既能一定程度提示外受与内生之"邪毒致变",在Hp相关胃病(helicobacter pylori-related gastric disease,HPGD)胃黏膜炎症、糜烂→萎缩伴肠化生、异型增生→癌变演变中加重和发生恶性转化的病理特征,也可初步体现不同病理阶段虚实不同证候发生和转化的病机特点。而缘于生物和环境形成之体质状态的可变性,可能亦与HPGD患者不同病理演变阶段的不同证候及其由实到虚、瘀兼夹状态发生和转化过程中群类趋同性易感之表型特征相关联。
Based on "inflammatory carcinoma china theory", the paper puts forward the view of "evil-toxin inducing variation" , and research the difference from cumulative effect on gene polymorphism micro-effect about helicobacter pylori (Hp) infest with inflammatory factor and mieroRNA. It holded that the correlated research not only to hint pathology characteristic of malignant transformation in variation from the gastric mucosa inflammation, anabrosis--+atrophy accompany intestinal metaplasia, dysplasia^canceration on the "evil-toxin inducing variation" of invade and endogeny in Helicobacter pylori-related gastric disease (HPGD) some extent; but also respond the pathogenesis characteristic of generating and converting about asthenia and sthenia syndromes in different pathology stages. The alterability of physical crasis state forming from living being and environment may be related with phenotype characteristic of congregation convergence easy respond in the proceed and convert process about different syndromes and from sthenia to deficiency, blood stasis inclusion state on HPGD.
作者
胡玲
陈昫
陈万群
龚琳
HU Ling CHEN Xu CHEN Wan-qun GONG Lin(Pi-wei institute, Guangzhou University of Chinese Medicine, Guangzhou 510405, China)
出处
《中国中医基础医学杂志》
CSCD
北大核心
2017年第6期816-818,共3页
JOURNAL OF BASIC CHINESE MEDICINE
基金
国家自然科学基金资助项目-(81373563)基于‘邪毒致变’探讨Hp相关胃病演变过程不同证候microRNAs和炎症因子基因多态性
广东省自然科学基金资助项目(S2012010010355)--Hp感染和MUC1-568A/G
IL1-B-511C/T基因多态性与慢性糜烂性胃炎不同证候关联的研究
华南中医药协同创新中心(2016KYTD07)-中医药防治脾胃病
脑病创新研究团队项目
广州中医药大学"高水平大学建设"项目[广中医研(2016)64号]-基于"湿热蕴毒"和Wnt新经典信号转导通路探讨Hp相关胃病脾胃湿热证
关键词
Hp相关胃病
邪毒致变
基因多态性
证候特征
体质状态
Helicobacter pylori-related gastric disease
Evil-toxin inducing variation
Gene polymorphism
Syndromes characteristic
Body constituting state