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外用重组人表皮生长因子联合硫酸羟氯喹片治疗糜烂型口腔扁平苔藓的疗效观察 被引量:16

Efficacy observation of rhEGF with hydroxychloroquine tablets in treating erosive oral lichen planus
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摘要 目的观察外用重组人表皮生长因子(rhEGF)与硫酸羟氯喹片治疗糜烂型口腔扁平苔藓的临床疗效。方法将口腔扁平苔藓患者60例随机分成2组,治疗组30例,使用外用重组人表皮生长因子与硫酸羟氯喹片,对照组30例,单独使用口腔硫酸羟氯喹片,治疗3个月后及停药3个月后复诊按3级疗效标准评定总体疗效。结果治疗组与对照组治疗3个月后的总有效率分别为93.33%和48.30%,停药3个月后复诊总有效率分别为91.23%和40.63%,两组均有统计学差异(P<0.05)。结论外用重组人表皮生长因子与硫酸羟氯喹片联合应用治疗口腔扁平苔藓有良好的临床疗效。 Objective To evaluate the clinical effect of rhECF's with hydroxychloroquine tablets (Plaquenil) on erosion oral lichen planus. Methods 60 cases with erosive oral lichen planus were chosen and randomly divided into two groups. The experimental group included 30 cases which were treated with rhEGF and Plaquenil. The other were in the control group treated with Plaquenil only. All the cases were treated for 3 months and had the subsequent visit after 3-month drug withdrawal The curative effects of the two groups were evaluated according to Level 3 curative standard and then compared. Results The total effective rates of experimental group and control group were 93.3%and 33.3% in three months(P〈0.05) , 91.23% and 73.63% were the effective rates of subsequent visit after three months(P〈0.05). Conclusion The rhEGF with Plaquenil shows better therapeutic response compared with Plaquenilin in sub- jects with oral lichen planus.
作者 陈月来 陈蕙萍 CHEN Yuelai CHEN Huiping(Department of Stomatology, Tongren Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200336, Chih)
出处 《口腔医学》 CAS 2017年第7期632-634,共3页 Stomatology
关键词 外用重组人表皮生长因子 硫酸羟氯喹片 口腔扁平苔藓 rhECF Plaquenil oral lichen planus
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