莫西沙星和左氧氟沙星对老年复治肺结核患者的治疗效果

Clinical effect of moxifloxacin and levofloxacin on retreatment pulmonary tuberculosis in the elderly

目的:探讨分析莫西沙星和左氧氟沙星对老年复治肺结核患者的治疗效果。方法:选择2014年5月至2015年4月收治的80例老年复治肺结核患者,将其随机分成观察组和对照组,每组各40例。两组均实施常规治疗,对照组在常规治疗的基础上给予左氧氟沙星,观察组在常规治疗的基础上实施莫西沙星治疗。观察并比较两组患者的治疗效果。结果:两组患者治疗后,观察组患者结核杆菌转阴率为97.50%,对照组患者转阴率为80.00%,组间比较差异具有统计学意义(χ2=6.135,P=0.013);观察组未出现病情恶化,对照组病情恶化的患者有6例(15.00%),观察组患者的治疗有效率高于对照组(χ2=7.709,P=0.008)。结论:莫西沙星在老年复治肺结核治疗中的效果较好,值得临床推广应用。

Objective：To investigate the clinical effect of moxifloxaein and levofloxacin on retreatment pulmonary tuberculosis in the elderly. Methods： 80 cases of elderly patients with retroatment pulmonary tuberculosis from May 2014 to April 2015 were randomly divided into observation group and control group, 40 cases in each group. The patients in control group were given levofloxacin on the basis of conventional therapy, and those in observation group were treated with moxifloxacin on the basis of conventional therapy. The therapeutic effects in the two groups were ob- served and compared. Result： After treatment, the negative conversion rate in observation group was 97.50 % and in control group was 80.00 %, which had statistical significance between the two groups （ P 〈 0.05 ） ; there was no deteriorated case in observation group and 6 cases in control group （ 15. 00 % ）. The therapeutic effect in observation group was significantly higher than that in control group （ X 2 = 7. 709, P 〈 0. 008 ）. Conclusion ： Moxifloxaein is effective in the treatment of retreatment pulmonary tuberculosis in the elderly, which is worthy of clinical application and promotion.