妊娠早中期给予阿司匹林常规口服对子痫前期高危孕妇的预防效果

Prophylactic Effect of Routine Oral Aspirin in Preeclampsia of High-Risk Pregnant Women during Early and Mid-Term

目的探讨在妊娠早中期给予阿司匹林常规口服对子痫前期高危孕妇的预防效果。方法选取我院2016年2月至2017年4月收治的孕13~16周合并有子痫前期高危孕妇200例,随机平均分为两组。干预组服用阿司匹林75 mg/d到孕28周,对照组不予任何抗凝治疗。比较两组孕妇治疗前后凝血指标及不良妊娠结局发生率。结果干预组的PT、TT水平均高于对照组,D-D水平低于对照组,差异有统计学意义(P<0.05)。干预组的子痫前期、子痫、胎盘早剥、早产、剖宫产、胎儿宫内生长受限发生率均低于对照组,差异有统计学意义(P<0.05)。结论合并有子痫前期高危孕妇在妊娠早中期给予阿司匹林常规口服预防性治疗,能显著减少子痫前期、子痫等相关不良妊娠结局,临床疗效显著。

Objective To explore the prophylactic effect of routine oral aspirin in preeclampsia of high-risk pregnant women during early and mid-term pregnancy. Methods 200 cases of high-risk pregnant women with preeclampsia during 13 to 16 weeks of pregnancy in our hospital from February 2016 to April 2017 were selected and randomly divided into two groups equally. The intervention group received 75 mg/d aspirin until 28 weeks of pregnancy, while the control group did not receive any anticoagulant therapy. The coagulation indicators before and after treatment and incidence of adverse pregnancy outcomes were compared between two groups. Results The PT and TT levels of intervention group were higher than those of control group, and the D-D level was lower than that of control group, with statistical differences （P 〈0.05）. The incidences of preeclampsia, eclampsia, placental abruption, premature delivery, cesarean section and intrauterine growth restriction of intervention group were lower than those of control group, with statistical differences （P 〈0.05）. Conclusions Routine oral aspirin in the prophylactic treatment of preeclampsia of high-risk pregnant women during early and mid-term pregnancy can significantly reduce the preeclampsia, eclampsia and related adverse pregnancy outcomes, with significant clinical curative effect.