妊娠高血压疾病产后血压转归与CGRP、IGF-1相关性分析

Correlative Analysis on Outcome of Postpartum Blood Pressure and CGRP, IGF-1 in Patients with Hypertensive Disorders Complicating Pregnancy

目的探讨分析妊娠高血压疾病(HDCP)产后血压转归与CGRP、IGF-1相关性。方法选取我院2013年1月至2016年3月收治的68例HDCP患者,根据患者产后40 d血压的转归情况,将其分为A组(血压恢复正常,38例)与B组(血压未恢复正常,30例)。比较两组患者入院第1 d及产后40 d的血清CGRP、IGF-1水平。结果两组患者入院第1 d的CGRP、IGF-1水平比较差异均无统计学意义(P>0.05);产后40 d,A组的CGRP、IGF-1水平均高于B组(P<0.05)。Pearson相关性分析显示,CGRP、IGF-1水平与HDCP产后血压转归均呈显著负相关(P<0.05)。结论 CGRP、IGF-1水平与HDCP患者的产后血压呈负相关,积极监测并提高CGRP、IGF-1水平可预测患者的产后预后,改善血压转归,促进母婴健康。

Objective To explore the correlation between outcome of postpartum blood pressure and CGRP and IGF-1 in hypertensive disorders complicating pregnancy （HDCP）. Methods 68 cases of HDCP patients admitted to our hospital from January 2013 to March 2016 were selected and divided into group A （blood pressure returning to normal, 38 cases） and group B （blood pressure not returning to normal, 30 cases） according to the patients＇ outcome of blood pressure 40 d after delivery. The serum CGRP and IGF-1 levels on first admission day and 40 d after delivery were compared between two groups. Results No statistical difference was found in the CGRP and IGF-1 levels on first admission day between two groups （P〉0.05）. 40 d after delivery, the CGRP and IGF-1 levels of group A were higher than those of group B （P 〈0.05）. Pearson correlative analysis showed that the CGRP and IGF-1 levels had significant negative correlation with the HDCP outcome of postpartum blood pressure （P〈0.05）. Conclusions The CGRP and IGF-1 levels have negative correlation with the postpartum blood pressure of HDCP patients. Positively monitoring and improving CGRP and IGF-1 levels can help to predict patients＇ postpartum prognosis, improve the outcome of blood pressure and promote maternal and child health.