替吉奥化疗联合同步放疗治疗老年食管癌的疗效及不良反应观察

Observation on the Curative Effect and Adverse Reactions of Tegafur, Gimeracil and Oteracil Chemotherapy Combined with Concurrent Radiotherapy in the Treatment of Elderly Esophageal Cancer

目的观察替吉奥化疗联合同步放疗治疗老年食管癌的疗效及不良反应。方法选取我院收治的80例老年食管癌患者,随机平均分为联合组与对照组。两组均给予三维适形调强放疗,联合组在放疗第1 d开始给予替吉奥口服,共治疗2个疗程。观察两组患者的疗效和不良反应。结果联合组的治疗总有效率为85.00%,显著高于对照组的65.00%(P<0.05)。两组患者的骨髓抑制、胃肠道反应、放射性肺炎及放射性食管炎发生率比较差异均无统计学意义(P>0.05)。结论采用替吉奥化疗联合同步放疗治疗老年食管癌患者,能够明显提高近期疗效,不良反应稍有增加但尚可耐受。

Objective To observe the curative effect and adverse reactions of tegafur, gimeracil and oteracil chemotherapy combined with concurrent radiotherapy in the treatment of elderly esophageal cancer. Methods 80 cases of elderly patients with esophageal cancer in our hospital were selected and randomly divided intO combination group and control group equally. Both groups received three-dimensional conformal radiotherapy, and the combination group started to receive oral tegafur, gimeracil and oteracil on the first day of radiotherapy. The curative effect and adverse reactions of two groups were observed. Results The total effective rate of combination group was 85.00%, significantly higher than 65.00% of control group （P 〈0.05）. No statistical difference was found in the incidences of bone marrow suppression, gastrointestinal reaction, radiation pneumonitis and radiation esophagitis between two groups （P 〈0.05）. Conclusions Tegafur, gimeracil and oteracil chemotherapy combined with concurrent radiotherapy in the treatment of elderly patients with esophageal cancer can significantly improve the short-term curative effect, with slightly increased but tolerable adverse reactions.