慢性胃炎及溃疡合并幽门螺杆菌感染患者采用四联药物根治性治疗后辅助铋剂模拟剂治疗的效果

Effect of Auxiliary Bismuth Simulant Agent in Patients with Chronic Gastritis and Ulcer Complicated with Helicobacter Pylori Infection after Radical Four-Drug Treatment

目的探讨慢性胃炎及溃疡合并幽门螺杆菌(Hp)感染患者采用四联药物根治性治疗后辅助铋剂模拟剂治疗的效果。方法选取我院2016年3月至2017年1月收治的慢性胃炎或消化性溃疡合并Hp感染患者40例,随机分为研究组和对照组各20例。对照组采用奥美拉唑、阿莫西林、克拉霉素、复方铝酸铋颗粒四联根治性治疗10 d,研究组在根治性治疗后给予铋剂模拟剂继续辅助治疗21 d。比较两组患者的Hp根治率、临床疗效及药物不良反应。结果研究组的Hp根治率为95.00%,显著高于对照组的70.00%(P<0.05)。研究组的总有效率为95.00%,显著高于对照组的65.00%(P<0.05)。两组患者的恶心呕吐、腹泻、头晕、黑便药物的发生率比较差异均无统计学意义(P>0.05)。结论慢性胃炎及消化性溃疡合并Hp感染患者采用四联药物根治后采用铋剂模拟剂辅助治疗可有效提高Hp根治率和临床疗效,并不增加药物不良反应。

Objectipe To explore the effect of auxiliary bismuth simulant agent in patients with chronic gastritis and ulcer complicated with helicobaeter pylori （lip） infection after radical four-drug treatment. Methods 40 cases of patients with chronic gastritis or peptic ulcer complicated with Hp infection admitted to our hospital from March 2016 to January 2017 were selected and randomly divided into study group and control group, with 20 cases in each group. The control group received omeprazole, amoxicillin, clarithromycin and bismuth potassium citrate for 10 days, while the study group received auxiliary bismuth simulant agent for 21 days after radical treatment. The lip radical rate, clinical curative effect and adverse drug reactions were compare between two groups. Results The lip radical rate of study group was 95.00%, significantly higher than 70.00% of control group （P 〈0.05）. The total effective rate of study group was 95.00%, significantly higher than 65,00% of control group （P 〈0.05）. No statistical difference was found in the incidences of nausea and vomiting, diarrhea, dizziness and black cessation between two groups （P 〉0.05）. Conclusions Auxiliary bismuth simulant agent in patients with chronic gastritis and ulcer complicated with lip infection after radical four-drug treatment can effectively improve the lip radical rate and clinical curative effect, without increased adverse drug reactions.