补肾益智活血法对老年痴呆患者认知功能及其血管炎性反应影响

Effect of Nourishing Kidney and Promoting Blood Circulation Method on Cognitive Function and Inflammatory Reaction of Patients with Senile Dementia

目的:观察补肾益智活血法对老年痴呆患者认知功能及其血管炎性反应的影响。方法:选取2014年6月—2016年6月至我院老年病科收治的老年痴呆患者120例。采用随机数字表法分为对照组和观察组,各60例。对照组患者给予盐酸多奈哌齐片,观察组给予补肾益智活血汤剂,4周为1个疗程,连续服用6个疗程。比较两组治疗前后痴呆疗效、认知能力、行为能力及炎症因子水平。结果:观察组恶化、无效、有效、显效、临床控制分别为0、21、20、15、4例;对照组恶化、无效、有效、显效、临床控制分别为1、32、14、13、1例;观察组总有效率高于对照组,观察组与对照组的总有效率分别为65.0%和46.67%,差异有统计学意义;观察组治疗前后MMSE-R积分分别为(15.9±2.6)、(19.2±3.1)分;对照组治疗前后MMSE-R积分分别为(15.8±3.2)、(17.8±2.9)分;观察组治疗前后BDS积分分别为(20.1±4.3)、(16.2±3.8)分;对照组治疗前后BDS积分分别为(20.7±3.4)、(18.9±4.1)分;两组治疗后认知能力及行为能力均较治疗前改善,且观察组优于对照组,差异有统计学意义(P<0.05);观察组治疗前后CRP水平分别为(9.7±2.4)、(3.1±2.8)分;对照组治疗前后CRP水平分别为(9.4±3.2)、(4.5±3.0)分;观察组治疗前后IL-6水平分别为(46.7±14.3)、(18.2±9.8)分;对照组治疗前后IL-6水平分别为(45.7±13.4)、(28.3±11.1)分;两组治疗后CRP水平、IL-6较治疗前改善,且观察组优于对照组,差异有统计学意义(P<0.05)。结论:补肾益智活血法可以改善老年痴呆患者认知功能,降低其炎性反应,提高疗效,值得临床应用。

Objective：To observe the clinical effect of nourishing kidney and promoting blood circulation method on cognitive function and inflammatory reaction of the patients with senile dementia. Methods：120 cases of senile dementia were selected from January 2012 to June 2014 in our hospital. The random number table method was divided the control group and the observation group,each of 60 cases. The control group were treated with Donepezil Hydrochloride Tablets,the observation group was given Bushen Huoxue Yizhi Decoction for 4 weeks for 1 courses,for taking 6 courses. Compare the therapeutic effect,cognitive ability,behavior ability and inflammatory factors of the two groups before and after treatment. Results：The observation group,markedly effective,ineffective,deterioration,clinical control were 0 cases,21 cases,20 cases,15 cases,4 cases;control group,markedly effective,ineffective,deterioration,clinical control were 1 cases,32 cases,14 cases,13 cases,1 cases;the observation group and the control group in the total efficiency were 65% and 46.67%,the difference was statistically significant;the observation group before and after treatment MMSE-R score was（15.9±2.6）,（19.2±3.1）points;the control group before and after treatment MMSE-R score was（15.8±3.2）,（17.8±2.9）points;observation group before and after treatment BDS score is（20.1±4.3）,（16.2±3.8）points;the control group before and after treatment BDS score was（20.7±3.4）,（18.9±4.1）points;cognitive ability and behavior ability of the two groups after treatment were improved after treatment,the observation group before treatment after CRP levels were（9.7±2.4）and（3.1±2.8）points;CRP level of the control group before and after treatment were（9.4± 3.2）and（4.5±3）points;IL-6 level in the observation group before and after treatment were（46.7±14.3）and（18.2±9.8）points;IL-6 level of the control group before and after treatment were（45.7±13.4）and（28.3±11.1）points;two groups after that,the level of CRP and IL-6 improved compared with before treatment. Conclusion：Nourishing kidney and promoting blood circulation method can improve cognitive function of senile dementia patients,reduce inflammatory reaction,improve the curative effect,it is worthy of clinical applicatio.