补肾活血促排卵汤治疗肾虚血瘀型多囊卵巢综合征所致不孕症的临床观察

Clinical Observation on Bushen Huoxue Cupailuan Decoction in the Treatment of Infertility Induced by Polycystic Ovary Syndrome of Kidney Deficiency and Blood Stasis

目的:探讨补肾活血促排卵汤对多囊卵巢综合征所致不孕症的临床效果及对相关指标的影响。方法:选取在我院进行治疗的肾虚血瘀型多囊卵巢综合征所致不孕症患者120例,按随机数字表分为观察组和对照组,各60例。从月经第5天起,对照组患者服用枸橼酸氯米芬胶囊50 mg,qd;观察组患者服用补肾活血促排卵汤每日200 m L,分早晚2次服用。3个月经周期为1个疗程,两组患者均服用1~2个疗程。观察两组患者治疗前后卵泡数量、子宫内膜厚度、卵巢体积、血清激素[胰岛素(INS)、促黄体激素(LH)、促卵泡激素(FSH)、垂体泌乳素(PRL)、睾酮(T)、雌二醇(E2)]水平,并比较两组患者治疗后妊娠率。结果:治疗前,两组患者卵泡数量、子宫内膜厚度、卵巢体积、血清激素水平比较,差异均无统计学意义(P>0.05)。治疗后,两组患者卵泡数量均增加,子宫内膜厚度和卵巢体积均增大,但观察组改善情况优于对照组,差异均有统计学意义(P<0.05);治疗后,两组患者FSH、E2水平显著升高,观察组患者INS、LH、PRL、T水平显著降低,且观察组患者血清激素水平均显著优于对照组,差异均有统计学意义(P<0.05)。观察组患者妊娠率为63.33%,显著高于对照组的46.67%,差异有统计学意义(P<0.05)。结论:补肾活血促排卵汤能显著改善肾虚血瘀型多囊卵巢综合征所致不孕症患者血清性激素水平,改善卵巢情况,提高妊娠率。

OBJECTIVE： To investigate the effects of Bushen huoxue cupailuan decoction on clinical effects and related indexes of infertility induced by polycystic ovary syndrome. METHODS： A total of 120 cases of polycystic ovary syndrome of kidney deficiency and blood stasis selected from our hospital were divided into observation group and control group according to random number table, with 60 cases in each group. From the 5th day of menstruation, control group was given Clomiphene citrate capsules 50 mg, qd; observation group was given 200 mL of Bushen huoxue cupailuan decoction, morning and night. Atreatment course lasted for 3 menstrnal cycle, both groups were treated for 1-2 courses. The number of follicles, endometrial thickness, ovarian volume and serum hormone levels （INS, LH, FSH, PRL, T, E2） were observed in 2 groups before and after treatment. The pregnancy rate were compared between 2 groups after treatment. RESULTS： Before treatment, there was no statistical significance in the number of follicles, endometrial thickness, ovarian volume or serum hormone levels between 2 groups （P〉0.05）. After treatment, the number of follicles, endometrial thickness and ovarian volume in 2 groups were all increased; the improvement of observation group was better than control group, with statistical significance （P〈0.05）. After treatment, the levels of FSH and E2 in 2 groups were increased significantly; the level of serum hormone in observation group was significantly better than control group, with statistical significance （P〈0.05）. The pregnancy rate of observation group was 63.33%, which was significantly higher than 46.67% of control group, with statistical significance （P〈0.05）. CONCLUSIONS： Bushen huoxue cupailuan decoction can effectively improve serum hormone lever, ovary condition and pregnancy rate in the infertility patients induced by polycystic ovary syndrome.