新孢子虫感染对大鼠主要器官病理变化的研究

Pathological changes of major organs in mice infected with Neospora caninum

为了研究动物感染新孢子虫后对各组织器官的影响,试验采用新孢子虫Nc-1株腹腔注射人工接种5周龄的SD大鼠,出现症状后分别采取肝脏、脾脏、肺脏、肾脏、脑和心脏制作常规石蜡切片,通过H.E.染色观察感染新孢子虫后各组织器官的病理变化。结果表明:显微镜下观察肝脏病理切片有淤血、坏死灶,肝细胞变性;脾脏出血;肺脏出血、淤血、水肿,肺泡壁增厚;肾脏出血,肾小管上皮细胞变性坏死;脑充血、水肿,神经元变性坏死;心肌纤维间血管充血。说明大鼠感染新孢子虫后会引起各组织器官不同程度的损伤及病理变化。

A study was conducted to research the effects of animal Neospora caninum infection on the tissues and organs. At the age of 5 weeks, the SD rats received intraperitoneal injection with Neospora caninum strain Nc - I. Routine paraffin sections were taken from the liver, spleen, lung, kidney, brain and heart. H.E. staining was used to observe the pathological changes of these organs after infection with Neospora caninum. The resuhs of pathological sections showed that congestion, necrotic foci, hepatocyte degeneration of the liver, hemorrhage of the spleen, hemorrhage, congestion, edema, alveolar wall thickening of the lung, hemorrhage, degeneration and necrosis of renal tubular epithelial ceils of the kidney, hyperemia, edema, neuronal degeneration and necrosis of the brain, and myocardial interstitial vascular congestion. It was concluded that Neospora caninum infection could lead to damage and pathological changes of various organs in rats.