弓形虫感染引起小鼠体内CD_8^+T淋巴细胞免疫的研究

Update on the CD_8^+ T cell immunity induced by Toxoplasma gondii infection in mice

弓形虫感染可诱导宿主机体产生强烈的CD_8^+T淋巴细胞免疫应答,这对机体有效控制弓形虫感染具有重要作用。在感染过程中,CD_8^+T淋巴细胞可刺激机体产生IFNγ等细胞因子,并促进细胞溶解,能够有效阻止机体内潜伏性感染的活化过程。然而,部分易感小鼠体内CD_8^+T淋巴细胞会在感染期间发生功能障碍。文章就慢性感染中CD_8记忆应答的发展及其功能障碍机制展开论述。

Toxoplasma gondii infection can induce a strong CD8＋ T cell immune response in the host, which plays an important role in the control of the infection of Toxoplasma gondii. During the course of infection, CD8 ＋ T cells can stimulate the body to produce IFNγ and other cyto- kines, leading to cell lysis, which can effectively prevent the activation process of latent infection in host. However, during the infection, CD8＋ T cells functional disorder could take place in some susceptible mice. In this article, the development of CDs memory response in chronic infection and the mechanism of functional dysfunction was reviewed and discussed.