摘要
目的通过观察复心合剂对阿霉素诱导的心衰大鼠DAG/PKC信号通路表达的影响,探讨DAG/PKC信号通路与心衰的关系。方法采用阿霉素诱导建立心衰大鼠模型,造模成功后给予复心汤、卡托普利药物干预4周,比较不同组别大鼠心肌细胞内DAG、PKC的表达量。结果心衰大鼠心肌细胞中DAG、PKC表达量增高;复心汤能够降低心衰心肌细胞中DAG、PKC表达量。结论复心汤能够改善心衰大鼠一般状态,抑制心衰心肌细胞中DAG/PKC信号通路的过度表达。
Objective： To investigate the relationship between DAG/PKC signaling pathway and heart failure by observing the effect of Fuxin Decoction on the expression of DAG/PKC signaling pathway in rats with Adfiamycin in- duced heart failure. Methods： The model of rats with heart failure was induced by Adriamycin. After successful modeling, the rats were treated with Fuxin Decoction and captopril for 4 weeks. The expressions of DAG and PKC in the myocardial cells of different groups were compared. Results： The expression of DAG and PKC in cardiac my- ocytes increased in heart failure rats, Fuxin Decoction could reduce the expression of DAG and PKC in heart failure heart muscle ceils. Conclusion： Fuxin Decoction can improve the general state of rats with heart failure and inhibit the over expression of DAG/PKC signaling pathway in heart failure cells.
作者
薛一涛
刘鹏
焦华琛
刘广志
陈炜
XUE Yitao LIU Peng JIAO Huachen et al(Affiliated Hospital of Shandong University of Traditional Chinese Medicine ,Shandong, Jinan 250000, Chin)
出处
《中国中医急症》
2017年第7期1141-1144,共4页
Journal of Emergency in Traditional Chinese Medicine
基金
国家自然科学基金(81273703)
关键词
复心汤
DAG
PKC
心衰
Fuxin Decoction
DAG
PKC
Heart failure
