血清CEA水平对胰腺癌患者淋巴结转移的预测价值

Predictive values of serum CEA level in lymph node metastasis of pancreatic cancer patients

目的:探讨血清癌胚抗原(CEA)水平对胰腺癌患者淋巴结转移的预测价值。方法:采用回顾性研究方法,研究时间为2013年2月到2016年4月,选择我院收治的胰腺癌患者72例作为研究对象,根据病理诊断判断为无淋巴结转移者22例(对照组)和有淋巴结转移者50例(观察组),两组都进行血清CEA水平检测与阳性率判定,同时进行临床病理特征的调查与影响因素分析。结果:两组的性别、年龄、体重指数、肿瘤部位、肿瘤家族史对比无明显差异(P>0.05),两组的肿瘤大小、临床分期与分化类型对比有明显差异(P<0.05);观察组的血清CEA水平与阳性率分别为(2 0.4 4±6.1 2)ng/ml和9 0.0%,都明显高于对照组的(9.13±4.10)ng/ml和50.0%(P<0.05);不同肿瘤大小、临床分期与分化类型的胰腺癌患者血清CEA阳性率对比都有统计学意义(P<0.05);Cox比例风险模型回归显示胰腺癌患者的CEA阳性率、肿瘤大小、临床分期、分化类型是导致淋巴结转移的主要独立危险因素(P<0.05)。结论:胰腺癌患者淋巴结转移比较常见,血清中CEA水平能有效判定胰腺癌的临床病理特征,有很好的检测诊断价值。

Objective：To discuss the predictive values of serum CEA level in lymph node metastasis of pancreatic cancer patients predict the predictive value of serum level of carcinoma embryonic antigen（CEA） in lymph node metastasis of pancreatic cancer patients.Methods：Using a retrospective study method,the study time were from February 2013 to April 2016,72 pancreatic cancer patients admitted in our hospital were selected as the research object.Accorded to the pathological diagnosis,there were 22 patients without lymph node metastasis（control group） and 50 patients with lymph node metastasis（observation group）,Two groups were given the serum CEA level detecting and the judgment of positive rate.At the same time,the survey and influencing factors of the clinical and pathological features were given analysis.Results：The two groups of gender,age,BMI,family history and tumor location compared were not significant difference（P〉0.05）.Two groups of tumor size,clinical stage and differentiation type compared were significant difference（P〈0.05）.The serum level of CEA and positive rate in the observation group were were （20.44±6.12）ng/ml and 90.0%.That were significantly higher than the control group of （9.13±4.10）ng/ml and 50.0%（P〈0.05）.The serum CEA levels in the different tumor size,clinical stage and differentiation types of pancreatic cancer were statistically significant（P〈0.05）.Cox proportional hazard regression model showed the positive rate of CEA,tumor size,clinical stage,differentiation were the independent risk factors for leading lymph node metastasis（P〈0.05）.Conclusion：Patients with pancreatic cancer lymph node metastasis was common,the serum CEA level can effectively determine the clinicopathological features that has very good detection and diagnosis value.