肝病治疗仪联合热毒宁治疗猩红热合并肝损伤患者的效果

The curative effect of therapeutic instrument of hepatopathy combined with Reduning injection in the treatment for patient with scarlet fever and hepatic injury

目的:探讨猩红热合并肝损伤患者临床治疗中采用肝病低频治疗仪联合热毒宁治疗的效果。方法:选取医院收治的94例猩红热合并肝损伤患者,采用数表法将其随机分为观察组和对照组,每组47例。对照组患者使用热毒宁联合贺维力(阿德福韦酯片)进行治疗,观察组于对照组治疗基础上辅以肝病治疗仪进行治疗,对比观察两组治疗效果、患者肝纤维化指标和应答率变化。结果:观察组治疗总有效率为95.7%,对照组患者总有效率为70.2%,观察组治疗总有效率明显优于对照组患者,差异具有统计学意义(x^2=7.283,P<0.05)。治疗后观察组患者肝纤维化透明质酸、Ⅲ、型前胶原、Ⅳ型胶原和层粘连蛋白4项指标较治疗前改善明显(t=3.42,t=2.83,t=2.74,t=2.52;P<0.05);对照组仅层粘连蛋白一项指标有所改善,较治疗前差异有统计学意义(t=2.15,P<0.05)。治疗后观察组患者联合应答率(CR)、病毒学应答(VR)、生化学应答(BR)和乙型肝炎E抗原(HBeAg)血清转换明显高于对照组,两组比较差异具有统计学意义(x2=5.235,x2=5.623,x2=4.993,x2=6.823;P<0.05)。结论:联合肝病低频治疗仪及热毒宁治疗猩红热合并肝损伤患者效果显著,可有效提高HBeAg等转换率,改善患者肝功能。

Objective： To investigate the curative effect of low-frequency therapeutic instrument of hepatopathy combined with Reduning injection in clinical treatment for patients with scarlet fever and hepatitis injury. Methods： 94 patients with scarlet fever and hepatitis injury were divided into observation group（47 cases） and control group（47 cases）. Patients of control group received the therapy of Reduning injection combined with tablet of adefovir dipivoxil, while the patients of observation group received the therapy of therapeutic instrument of hepatopathy combined with the therapy of control group. The changes of curative effect, indicator of hepatic fibrosis and response rate between two groups were observed. Results： The total effective rate of the observation group（95.7%） was significantly higher than that of control group（70.2%）（χ^2=7.283, P〈0.05）. In observation group, the hepatic fibrosis hyaluronic acid, Ⅲ、type procollagen, Ⅳ type collagen and laminin of posttreatment were significant improvement than that of pre-treatment（t=3.42, t=2.83, t=2.74, t=2.52, P〈0.05）. While in control groups, only the laminin of post-treatment was significant improvement than that of pre-treatment（t=2.15, P〈0.05）. After treatment, CR, VR, BR and HBeAg of observation group were significant higher than that of control group（χ^2=5.235, χ^2=5.623, χ^2=4.993, χ^2=6.823, P〈0.05）. Conclusion： The combination of low-frequency treatment of hepatopathy and Reduning injuection for the treatment of patients with scarlet fever and hepatic injury has significant effect, and it can effectively enhance the conversion rate of HBeAg, and improve liver function of patients. Therefore, it is worthy to be further promoteed in the clinical application.