超低频经颅磁刺激联合利培酮对女性精神分裂症的疗效

Efficacy of ultra-low frequency transcranial magnetic stimulation combined with risperidone on female schizophrenia

目的探讨超低频经颅磁刺激联合利培酮对女性精神分裂症患者的疗效。方法将2012年8月-2014年4月在某省精神卫生中心就诊的符合研究标准的60例女性精神分裂症患者按随机数字表法分为研究组(超低频经颅磁刺激联合利培酮治疗,n=30)和对照组(单用利培酮治疗,n=30)。于治疗前、治疗第11天、治疗1月时采用阳性和阴性症状量表(PANSS)对所有患者进行评定。结果两组治疗第11天、1月时的PANSS总评分及各分量表评分均低于治疗前,差异均有统计学意义(P均<0.01)。治疗第11天时,研究组的阳性症状量表和幻觉评分均低于对照组(t=2.09,P=0.04;t=2.36,P=0.02);治疗1月时,两组PANSS总评分及各分量表评分差异均无统计学意义(P均>0.05)。结论超低频经颅磁刺激联合利培酮对女性精神分裂症患者症状的改善在短期内优于单用利培酮,但其优势并不持久。

Objective To explore the efficacy of ultra - low frequency transcranial magnetic stimulation combined with risperidone on the patients with schizophrenia. Methods A total of 60 female patients with schizophrenia who met the study standards from a center of mental health in August 2012 - April 2014 were included in the study. All patients were randomly divided into study group （ultra - low frequency transcranial magnetic stimulation combined with risperidone treatment, n =30） and control group （single risperidone treatment, n = 30） . All patients were assessed by Positive and Negative Syndrome Scale （ PANSS） before treatment, 11 days and 1 month after treatment. Results After treatment for 11 days and 1 month, the PANSS total score and each subscale score were lower than those before treatment, the differences were statistical significance （all P 〈0. 01 ）. After treatment 11 days, the scores of positive symptom scale and hallucination in the study group were lower than those in the control group = 2. 09, P =0. 04; t=2.36, P =0. 02）. After treatment 1 month, the PANSS total score and each subscale score were not statistical difference between two groups （all P 〉0. 05）. Conclusion Risperidone combined with ultra - low frequency transcranial magnetic stimulation is more effective than single risperidone treatment for the female schizophrenia in a short term, but the advantage is not in a long time.