乳腺增生人群甲状腺结节的发病率及影响因素

Incidence and influencing factors of thyroid nodules in patients with mammary hyperplasia

目的探讨女性乳腺增生人群的甲状腺结节发病率及影响因素。方法选取2015年3~6月健康体检的企事业单位的60岁以下女性,超声诊断乳腺增生患者549例,另选取同期体检的企事业单位60岁以下女性经超声检查非乳腺增生女性480例作为对照组,收集体检资料,用t检验、多因素Logistic回归分析方法等分析影响该人群甲状腺结节发病的因素。结果与非乳腺增生组相比,乳腺增生组甲状腺结节的患病率升高,为54.5%(P<0.05)。乳腺增生人群中,甲状腺结节组较非结节组年龄较大,TC、LDL水平较高(均P<0.05)。经多因素Logistic回归分析显示:年龄(OR∧=1.487,95%CI:1.159,1.625)、TC(OR∧=1.038,95%CI:1.009,1.092)、LDL-C(OR∧=1.296,95%CI:1.067,1.441)是乳腺增生人群甲状腺结节发病的危险因素。结论乳腺增生人群甲状腺结节的患病率随年龄增长而升高,影响其合并甲状腺结节的危险因素包括年龄、总胆固醇和低密度脂蛋白胆固醇。

To explore the incidence and influencing factors of thyroid nodules in patients with mammary gland hyperplasia. Methods Among the women under the age of 60 who had physical examination in our hospital from March to June in 2015, 549 were diagnosed with hyperplasia of mammary glands and enrolled into mammary hyperplasia group, and 480 patients without mammary hyperplasia were collected as control group. Their medical data were collected. Chi-square test and the multivariate logistic regression analysis were used to analyze the factors influencing the occurrence of thyroid nodules. Results Compared with the control group, the incidence of thyroid nodules （54.5%） was significantly higher in the mammary hyperplasia group （ p〈 0.05）. In the crowd with hyperplasia of mammary glands, the average onset age of the thyroid nodule group was older than that of the nonnodule group （p 〈 0.05）, the levels of TC and LDL-C were higher than those of the non-nodule group （p 〈 0.05）. Multivariable logistic regression analysis showed that age （OR = 1.487, 95% CI： 1.159, 1.625）, TC （OR = 1.038,95% CI： 1.009, 1.092） and LDL - C （OR = 1.296, 95% CI： 1.067, 1.441） were the risk factors of thyroid nodules. Conclusions Incidence of thyroid nodules in female patients with mammary gland hyperplasia increases with age.Age, TC and LDL-C are the risk factors of thyroid nodules for female mammary gland hyperplasia.