北京市宫颈癌17年发病率变化及趋势分析

Analysis of incidence change of cervical cancer in Beijing during past 17 years

目的分析1993-2008年北京市宫颈癌的发病率、发病趋势及发病年龄,了解北京市宫颈癌的发病特点。方法根据北京市肿瘤登记处提供的1993至2008年全部宫颈癌病人的肿瘤登记资料,对宫颈浸润癌病历做回顾性调查。采集每份病例的流行病学数据。用统计学软件SPSS 20.0进行数据处理和统计分析。发病趋势计算采用美国国家癌症中心的Joinpoint软件进行统计分析及预测。结果 1993-2008年间,北京市平均宫颈癌粗发病率为3.54/100 000人口;WHO年龄标化发病率为2.91/100 000人口。1999-2008年发病率上升明显,以每年19.58%的速度快速上升。1993年中位发病年龄是67岁,2008年下降到45岁。40~49年龄组的发病率增加最明显,60~69年龄段和70岁以上年龄段发病率持续下降。结论宫颈癌发病率的明显上升和年轻化是北京市宫颈癌发病的主要特征。

Objective To explore the incidence change and the epidemiological characteristics of cervical cancer in Beijing from 1993 to 2008. Methods A total of 4100 patients with cervical cancer were included from the Statistics Database of Beijing cancer Registry （BJCaR） from 1993 to 2008. We retrospectively reviewed all original cases which we retrieved from the reported hospitals. Totally 3 641 registered cases were verified. Results The crude rates of incidence wase 3.54 per 100 000 women during 1993 to 2008. The average WHO age-standardized incidence rate was 2.91 per 100, 000 women. There was a decrease in the incidence annually by 8.0% during 1993-1996 and a rapid increase annually by 19.58% after 1999 （P 〈 0.01）. The most obvious increase was in 40-49 years group, followed by 30-39 years-group after 2003. The median age was 67 years old in 1993, while the median age decreased to 45 years old in 2008. Conclusion The cervical cancer incidence has shown a continuous fast rise and the proportion of young patients has been increasing since 1999 in Beijing.