抑郁对帕金森病患者执行功能的影响

The influence of depression on executive function in patients with Parkinson's disease

目的探讨抑郁对帕金森病(PD)患者执行功能的影响。方法对41例PD患者及20例对照组进行整体认知功能、执行功能及抑郁状况的评定。整体认知功能评定使用简易智力状态量表(MMSE);执行功能评定包括言语流畅性测验(VFT),连线测验(TMT),Stroop字色干扰测验(SCWT),画钟测验(CDT),数字符号替换测试(DSST)及数字广度测试(DST)等;使用贝克抑郁自评量表(BDI)评估抑郁状态。结果抑郁组SFT,PFT,DST,DSST,CDT,TMA,TMB,Stroop-B,Stroop-C,SIE评分均差于对照组(P<0.05);非抑郁组PFT,DST,DSST,TMA,TMB,Stroop-C,SIE评分差于对照组(P<0.05);与非抑郁组比较,抑郁组SFT,PFT,DST,DSST,TMA,TMB,Stroop-B,Stroop-C,SIE评分较差(P<0.05)。结论 PD患者存在明显的执行功能障碍,抑郁可以明显加重PD患者的执行功能障碍。

Objective To assess the effect of depression on executive function in patients with Parkinson＆#39;s Disease.Methods The overall cognitive function, executive function and depression status of 41 PD patients and 20 healthy controls were evaluated. The overall cognitive function was assessed by using the Mini Mental State Scale （MMSE）. The executive function evaluation was composed of Verbal Fluency Test （VFT）,Trail Making Test （TMT）, Stroop Color Word Test （SCWT）, Clock Drawing Task （CDT）, Digit Symbol Substitution Test （DSST） and Digit Span Test （DST）. The depression was assessed by using the Beck Depression Inventory（BDI）.Results SFT, PFT, DST, DSST, CDT, TMA, TMB, Stroop-B、Stroop-C, SIE scores were significantly worse in DPD group than those in control group. PFT, DST, DSST, TMA, TMB, Stroop-C, SIE scores were significantly worse in NPD group than those in control group（P〈0.05）. SFT, PFT, DST, DSST, TMA, TMB, Stroop-B, Stroop-C, SIE scores were significantly worse in DPD group than those in NPD group.Conclusion Patients with Parkinson＆#39;s disease existed obvious executive dysfunction. And depression could significantly increase the executive dysfunction of PD patients.