135例溃疡性结肠炎相关危险因素的临床特征分析

Clinical analysis of risk factors associated in 135 patients with ulcerative colitis

[目的]分析135例溃疡性结肠炎(UC)患者的临床特征,以分析其患病的可能危险因素。[方法]对2015年6月~2016年6月我院UC专病门诊就诊的135例UC患者的性别、确诊年龄和发病相关危险因素进行调查分析。[结果]UC在性别上男性略高于女性,男女之比为1.29:1;平均确诊年龄36.5岁,以30~39岁最多(31.11%);患者长期居住地多为小城镇和农村,占57.78%;从事脑力劳动者占55.56%,从事体力劳动者占44.44%;平时饮用牛奶患者占51.85%;服用过非甾体类抗炎药(NSAIDS)药物患者占26.67%;饮酒占28.89%。76例男性患者中饮酒占50.00%,吸烟患者占36.84%;59例女性患者中口服避孕药史占20.34%。135例患者中,阑尾切除史3例,有UC患者家族史14例(10.37%),其中炎症性肠病家族史2例,大肠癌家族史8例,慢性腹泻的家族史6例,其中炎症性肠病合并大肠癌家族史1例,大肠癌合并慢性腹泻家族史1例。[结论]心理压力、饮用牛奶和遗传因素可能是发病的高危因素,应加强慢病管理,利用大数据和长期随访进一步分析,以预防疾病发生。

[Objective]To analyze the clinical characteristics of 135 patients with ulcerative colitis,and to analyze the possible risk factors of the disease.[Methods]A total of 135 patients with ulcerative colitis were enrolled in the study in Jiangsu Provincial Hospital of TCM from June 2015 to June 2016.The gender,age and related risk factors of ulcerative colitis were investigated and analyzed.[Results]Ulcerative colitis was slightly higher in males than in females.The ratio of male to female was 1.29：1;the average diagnosis age was 36.5years old,the highest was 30-39 years old（31.11%）;the long-term residence was small towns and villages,accounting for 55.76%;55.46% of the patients were mental workers;51.85% of the patients drinking milk,26.67%taking NSAIDS,28.89% drinking alcohol,Smoking patients accounted for 36.84%of male patients,female oral contraceptive history accounted for 20.34%;3people had appendectomy,14 patients with UC family history（10.37%）,of which 2patients with family history of IBD,8patients with family history of colorectal cancer,6patients with chronic diarrhea family history,including 1case of inflammatory bowel disease combined with colorectal cancer family history,1case of colorectal cancer with chronic diarrhea family history.[Conclusion]Mental stress,drinking milk and genetic factors may be a high risk factor for the onset of disease,management should be strengthenedusing large data and long-term fol-low-up to the further analysis.