清肠愈疡汤联合美沙拉嗪治疗溃疡性结肠炎的临床疗效观察

The clinical effect of Qingchang Yuyang decoction combined with mesalazinein treating ulcerative colitis

[目的]观察清肠愈疡汤保留灌肠联合美沙拉嗪颗粒口服治疗溃疡性结肠炎(UC)的临床疗效。[方法]选取我院收治的108例UC患者为研究对象,随机分为对照组与联合组,每组各54例,对照组予以单用美沙拉嗪颗粒治疗,联合组予以清肠愈疡汤保留灌肠联合美沙拉嗪颗粒口服。对2组患者临床效果进行观察对比。[结果]联合组临床症状各项评分、结肠镜检积分、CRP、IL-1β和复发率明显低于对照组(P<0.05)。[结论]清肠愈疡汤保留灌肠联合美沙拉嗪治疗UC可有效降低炎性指标,改善临床症状,且复发率低,有一定的临床应用价值。

[Objective]To investigate the clinical effect of Qingchang Yuyang decoction in retaining ulcerative colitis with enema combined with mesalazine.[Methods]108 patients with ulcerative colitis were enrolled in this study.54 cases were divided into control group and combined group randomly.The control group was treated with mesalazine granules alone.The combined group was managed with Qingchang Yuyu decoctionpreserving enema and mesalazine granules.The clinical effects of the two groups were observed and compared.[Results]The scores of clinical symptoms,colonoscopy score,CRP,IL-1β and recurrence rate were significantly lower in the combined group than in the control group（P〈0.05）.[Conclusion]The treatment of ulcerative colitis with Qingchang Yuyang Decoction and mesalazine can relieve the inflammatory reaction and ameliorate the clinical symptoms,and the recurrence rate is lower.The method has the relatively valuable in the ulcerative colitis.