摘要
目的:探讨补肾温阳化瘀法对子宫内膜异位症患者子宫内膜腺上皮细胞骨桥蛋白(OPN)与基质金属蛋白酶-9(MMP-9)的影响。方法:选择我院2013年4月~2016年4月收治的92例子宫内膜异位症患者,分为对照组与观察组,各46例,对照组行常规西医治疗,观察组行补肾温阳化瘀法治疗,比较两组OPN及MMP-9,雌二醇(E2)、促黄体生成素(LH)、卵泡刺激素(FSH),肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-8(IL-8),CD3^+、CD4^+、CD8^+、CD4^+/CD8^+,临床疗效及安全性。结果:治疗后,观察组OPN、MMP-9,TNF-α、IL-6、IL-8,CD8^+低于对照组,观察组CD3^+、CD4^+、CD4^+/CD8^+高于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,不良反应率低于对照组(P<0.05)。结论:补肾温阳化瘀法可下调子宫内膜异位症患者子宫内膜腺上皮细胞OPN及MPP-9表达。
Objective：To investigate the effects of bushen wenyang huayu treatment on serum levels of endometrial glandular epithelial cells osteopontin （OPN） and matrix metalloproteinases-9 （MMP-9） in patients with endometriosis.Methods：92 cases with endometriosis who were treated in our hospital from April 2013 to April 2016 were selected and randomly divided into the control group and the observation group with 46 cases in each group.The patients in the control group were treated with western medicine,while the patients in the observation group were treated with bushen wenyang huayu method.Then the serum levels of OPN,MMP-9,estradiol （E2）,luteinizing hormone （LH）,follicle-stimulating hormone （FSH）,tumor necrosis factor-or （TNF-α）,interleukin-6 （IL-6）,interleukin-8 （IL-8）,CD3^＋,CD4^＋,CD8^＋ and CD4^＋/CD8^＋,the clinical efficacy and safety in the two groups were observed and compared before and after the treatment.Results：After treatment,the serum levels of OPN,MMP-9,TNF-α,IL-6,IL-8 and CD8＋ in the observation group were lower than those of the control group,while the levels of CD3^＋,CD4^＋ and CD4^＋/CD8^＋ were higher,and the differences were statistically significant （P〈0.05）.The total effective rate of the observation group was higher than that of the control group,while the incidence of adverse reactions was lower （P〈0.05）.Conclusion：Bushen wenyang huayu method can reduce the serum levels of OPN endometrial glandular epithelial cells and MPP-9 of patients with endometriosis.
出处
《现代生物医学进展》
CAS
2017年第18期3520-3523,3527,共5页
Progress in Modern Biomedicine
基金
新疆维吾尔自治区自然科学基金项目(20112A038)
