滑膜炎颗粒联合中药熏蒸治疗膝关节创伤性滑膜炎患者的临床疗效及机制

Efficacy and Mechanism of Huamoyan Granules Combined with Chinese Medicine Fumigation in Treatment of Traumatic Synovitis of Knee Joint

目的:研究滑膜炎颗粒联合中药熏蒸对膝关节创伤性滑膜炎患者临床疗效及其可能机制。方法:选取2014年7月至2015年7月我院接诊的膝关节创伤性滑膜炎患者80例作为本次研究对象并将其随机分为两组。对照组采用滑膜炎颗粒治疗,观察组采用滑膜炎颗粒联合中药熏蒸治疗,观察两组患者治疗前后视觉模拟疼痛(VAS)、膝关节功能(HSS)评分,症状体征积分,血清肿瘤坏死因子-α(TNF-α)、白介素-1β(IL-1β)、白介素-6(IL-6)水平的变化及治疗疗效。结果:治疗后,观察组VAS评分显著低于对照组【(2.30±0.40)分vs(4.69±0.42)分】(P<0.05),HSS评分显著高于对照组【(90.28±6.97)分vs(69.47±5.83)分】(P<0.05),疼痛、肿胀、活动度、临床症状积分均显著低于对照组(P<0.05),血清TNF-α、IL-1β、IL-6水平均显著低于对照组(P<0.05),总有效率明显高于对照组【90.00%(36/40)vs70.00%(28/40)】(P<0.05)。结论:滑膜炎颗粒联合中药熏蒸治疗膝关节创伤性滑膜炎临床效果显著优于单用滑膜炎颗粒治疗,可能与其有效抑制TNF-α、IL-1β、IL-6的表达有关。

Objective：To study the efficacy and mechanism of huamoyan granules combined with chinese medicine fumigation in the treatment of traumatic synovitis of knee Joint.Methods：80 patients of traumatic synovitis of knee joint who were treated from March 2014 to March 2015 in our hospital were selected as research objects and randomly divided into two groups.The control group was treated with huamoyan granules,while the observation group was treated with huamoyan granules combined with chinese medicine fumigation.Then the visual analogue pain（VAS）,knee joint function （HSS） score,symptom and sign score,serum tumor necrosis factor-α（TNF-α）,interleukin-1 β（IL-1 β）,interleukin-6（IL-6） levels,therapeutic efficacy before and after treatment were compared between two groups.Results：After treatment,the VAS score in the observation group was significantly lower than that of the control group[（2.30± 0.40）score vs （4.69± 0.42）score]（P〈0.05）;HSS score was significantly higher than that of the control group [（90.28± 6.97） score vs （69.47± 5.83） score] （P〈0.05）.The pain,swelling,activity,clinical symptom score were lower than those of the control group （P 〈0.05）,the serum TNF-α,IL-1β,IL-6 were lower than those of the control group （P 〈 0.05）.the total effective rate of observation group was statistically higher than that iofthe control group[90.00%（36/40）vs70.00%（28/40）]（P〈0.05）.Conclusions：Huamoyan granule combined with Herbal Fumigation was better than single Huamoyan granule in the treatment of traumatic synovitis of knee joint,which might be related to decrease the TNF-α,IL-1 β,IL-6 levels.