同型半胱氨酸水平与女性绝经期骨质疏松相关性研究

Correlative Research of the Homocysteine Levels with Osteoporosis in Postmenopausal Women

目的:通过分析女性绝经期不同骨密度人群的血浆同型半胱氨酸(HCY)指标,探讨同型半胱氨酸在女性绝经期骨质疏松发生过程中的作用及其潜在的临床价值。方法:收集2014年3月至2016年3月我院体检中心进行体检的女性绝经期妇女(>60岁)血样标本共计625例,根据体检的骨密度报告对其进行分组,骨质疏松组215例,骨量减少组309例,骨量正常组101例,测量每组的同型半胱氨酸水平。结果:骨密度程度与同型半胱氨酸水平存在负相关关系(rs=-0.763,P=0.046),三组之间的同型半胱氨酸水平也存在显著差异(F=4.807,P<0.016),其中骨质疏松组指标最高,骨量正常组指标最低。结论:同型半胱氨酸是重要的骨代谢指标,在衡量绝经期妇女骨质疏松进展中具有重要的意义。

Objective：By analyzing the different bone mineral density in postmenopausal women crowd plasma homocysteine （HCy） indicators on the role of homocysteine in the process of osteoporosis in postmenopausal women and its potential clinical value.Methods：Collected from March 2014 to March 2016 XX Hospital Medical Center for medical examination of female postmenopausal women （〉 60 years） blood samples totaling 625 cases,according to the medical report of their bone density group,osteoporosis group of 215 cases,osteopenia group of 309 cases,101 cases of normal bone mass,measuring homocysteine levels for each group.Results：Between the three groups of homocysteine levels were significantly different （P〈0.05）,in which the highest set of indicators ofosteoporosis,bone mass index normal minimum.Conclusion：Homocysteine is an important indicator of bone metabolism,and has important significance in postmenopausal women with osteoporosis to measure progress.