重度烧伤患者应用重组人生长激素治疗的临床效果

Clinical Effect of Recombinant Human Growth Hormone Therapy in Patients with Severe Burn

目的:研究重组人生长激素对重度烧伤的应用治疗效果。方法:选取重度烧伤患者42例。根据随机数表法,将所有患者分为观察组(n=21)和对照组(n=21),观察组在对照组的基础上给予重组人生长激素治疗。结果:对照组术后24 h血红蛋白及总蛋白水平均低于实验组,差异无统计学意义(P>0.05);对照组术后1周血红蛋白水平为(95.57±11.41)g/L,低于实验组的(137.91±14.29)g/L(t=3.726,P<0.001);对照组术后2周血红蛋白水平为(80.89±11.38)g/L,低于实验组的(131.28±13.47)g/L(t=3.917,P<0.001);实验组术后1周总蛋白水平为(61.47±5.19)g/L,高于对照组的(39.18±2.76)g/L(t=3.927,P<0.001);实验组术后2周总蛋白水平为(55.78±6.38)g/L,高于对照组的(36.81±5.17)g/L(t=3.847,P<0.001)。实验组术后24h的TNF-α和IL-6高于对照组,差异无统计学意义(P>0.05);实验组术后2周的TNF-α、IL-6均明显低于对照组,差异有统计学意义(P<0.001);实验组术后2周的TNF-α、IL-6均明显低于对照组,差异有统计学意义(P<0.001);观察组的住院时长为(47.82±7.46)天,显著低于对照组的(79.36±8.10)天(t=4.275,P<0.001);观察组的供皮区、植皮区、深Ⅱ度痂下愈合时间均显著低于对照组的,差异有统计学意义(P<0.001)。结论:rh GH对重度烧伤的疗效非常显著,值得在临床中推广。

Objective：To study the effect of recombinant human growth hormone on the treatment of severe burn.Methods：42 cases of severe burn patients in our hospital from February 2013 to December 2015 were divided into observation group （n=21） and control group （n=21） according to the random number table method.Patients in the observation group was given recombinant human growth hormone therapy on the basis of the control group.Results：At postoperative 24h,the hemoglobin and total protein levels were lower in the control group than in the experimental group,but the difference was not statistically significant （P〉0.05）.After one week,the hemoglobin level of control group was（95.57± 11.41）g/L,lower than that of experimental group （137.91± 14.29）g/L （t=3.726,P〈0.001）.After 2 weeks,the hemoglobin level of control group was（80.89± 11.38）g/L,lower than that of experimental group （131.28± 13.47） g/L （t=3.917,P〈0.001）.As for the total protein level,it was （61.47± 5.19） g/L in the experimental group after 1 weeks,higher than （39.18± 2.76） g/L in the control group （t=3.927,P〈0.001）.Yet it was still higher in the experimental group [（55.78± 6.38） g/L] after 2 weeks than in the control group [（36.81± 5.17） g/L] （t=-3.847,P〈0.001）.The experimental group had higher TNF-alpha and IL-6 levels than the control group after 24h,but the difference was not statistically significant （P〉0.05）.At 2 weeks after surgery,the TNF-alpha and IL-6 levels in the experimental group were significantly lower than in the control group,the difference was statistically significant （P〈0.001）.The length of hospitalization in the experimental group was （47.82± 7.46） days,significantly shorter than in the control group [（79.36± 8.10） days] （t=4.275,P〈0.001）.The healing time of the graft area,donor skin and deep second degree under the scab were significantly shorter in the experimental group than in the control group,and the difference was statistically significant （P〈0.001）.Conclusion：RhGH is significant in the treatment of severe burns,so it is worth promoting in clinic.