米非司酮联合桂枝茯苓丸治疗子宫内膜异位症的临床效果分析

Clinical Efficacy of Mifepristone Combined with Guizhi Fuling Capsule in The Treatment of Endometriosis

目的:分析米非司酮联合桂枝茯苓丸治疗子宫内膜异位症的临床效果。方法:106例子宫内膜异位症患者按抽签法分为对照组(n=53)与实验组(n=53),对照组采用米非司酮治疗,实验组基于对照组加以桂枝茯苓丸治疗,比较两组的临床疗效,治疗前后血清癌抗原125(CA125)、癌抗原199(CA199)、血管内皮生长因子(VEGF)、超氧化物歧化酶(SOD),白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、肿瘤坏死因子-α(TNF-α)、超敏C反应蛋白(hs-CRP)、血浆黏度、全血黏度、红细胞聚集指数的变化。结果:实验组的治疗总有效率为94.33%,显著高于对照组,差异有统计学意义(P<0.05)。实验组治疗后血清CA125、CA199、VEGF、SOD、IL-6、IL-8、TNF-α、hs-CRP水平、血浆黏度、全血黏度、红细胞聚集指数均明显低于对照组(P<0.05)。结论:米非司酮联合桂枝茯苓丸治疗子宫内膜异位症的临床疗效确切,可能与其抗炎、抗氧化和改善血液流变学作用有关。

Objective：To analyze the clinical effects of mifepristone and guizhi fuling capsules on the endometriosis and serum levels of cancer antigen 125 （CA125） and cancer antigen 199 （CA199）.Methods：106 cases with endometriosis who were treated in our hospital were selected and randomly divided into the control group and the experimental group with 53 cases in each group.The patients in the control group were treated with mifepristone,while the patients in the experimental group were treated with guizhi ruling capsule on the basis of the control group.Then the clinical curative effect,serum levels of CA125,CA199,vascular endothelial growth factor （VEGF）,superoxide dismutase （SOD）,interleukin-6 （IL-6）,interleukin-8 （IL-8）,tumor necrosis factor-α （TNF-α）,hypersensitive c-reactive protein （hs-CRP）,whole blood viscosity,plasma viscosity and erythrocyte aggregation in the two groups were observed and compared before and after the treatment.Results：The effective rate of the experimental group was significantly higher than that of the control group（P〈0.05）;The serum levels of CA125,CA199,VEGF,SOD,IL-6,IL-8,TNF-α,hs-CRP,whole blood viscosity,plasma viscosity and erythrocyte aggregation indexes of the experimental group were significantly lower than those of the control group（P〈0.05）.Conclusion：Mifepristone and guizhi fuling capsule had better clinical effects on the endometriosis,which could reduce the serum levels of CA125 and CA199.