肥胖微环境促进脂肪纤维化的发病机制研究进展

Pathogenesis Progress of Obesity Environment in Promoting Adipose Tissue Fibrosis

现代研究发现脂肪组织的功能不仅仅只是储存以及释放脂类,还作为人体的内分泌腺,在维持机体代谢平衡方面具有重要的作用。而肥胖状态时脂肪组织的分泌功能紊乱,炎症因子与脂肪因子分泌失衡,打破了机体的代谢平衡。更糟糕的是,脂肪组织形成慢性低度炎症以及缺氧微环境,引起胶原的异常沉积,脂肪组织纤维化,从而破坏脂肪组织正常功能,可能进一步导致糖尿病以及肿瘤的产生。因此,本文主要概述肥胖引起的慢性炎症和缺氧微环境通过分泌炎症因子、上调缺氧诱导因子的表达,进而改变脂肪细胞外基质的组成,最终促进脂肪纤维化的发生的机制。

Modern studies reveal that the adipose tissue not only storages and releases lipids but also plays a pivotal role in maintaining the body＆#39;s metabolic balance,as an endocrine gland.However,the secretion function of adipose tissue is disturbed in obesity.Obesity breaks the balance between inflammatory factor and adipocytokines.As a result,the balance of overall metabolism is broken.What＆#39;s worse,the imbalance results in chronic inflammation and hypoxia,which promote collagen deposition,adipose tissue fibrosis and dysfunction.Furthermore,fibrosis may initiates diabetes and cancer.Therefore,this review summarizes the mechanism of adipose tissue fibrosis by obesity-induced chronic inflammation and hypoxia microenvironment,mainly through changing the extracellular matrix by secretion of inflammatory factor and inducement of hypoxia-inducible factor.