复方甘草酸苷辅助治疗寻常型银屑病的临床疗效及安全性分析

Clinical effect and the safety of compound glycyrrhizin in the adjuvant treatment of psoriasis vulgaris

目的探讨复方甘草酸苷辅助治疗寻常型银屑病的临床疗效及安全性。方法选取射阳县疾病预防控制中心皮肤科2015年9月—2016年8月收治的寻常型银屑病患者64例,根据治疗方案不同将患者分为对照组11例和观察组53例。对照组患者给予外用蒽林软膏治疗,观察组患者在对照组基础上加服复方甘草酸苷胶囊治疗,两组患者均连续治疗1个月。比较两组患者治疗前后银屑病面积与严重性指数(PASI)评分、临床疗效及不良反应发生情况。结果治疗前两组患者PASI评分比较,差异无统计学意义(P>0.05);治疗后观察组患者PASI评分低于对照组(P<0.05)。观察组临床疗效优于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论复方甘草酸苷辅助治疗寻常型银屑病的临床疗效确切,可有效改善患者皮损情况,且不良反应少。

Objective To evaluate the clinical effect and the safety of compound glycyrrhizin in the adjuvant treatment of psoriasis vulgaris. Methods A total of 64 cases of patients with psoriasis vulgaris were selected from September 2015 to Au- gust 2016 in Sheyang County Disease Prevention and Control Center, which were divided into control group （n = 11 ） and obser- vation group （n = 53 ）. Control group was treated with anthralin ointment, observation group was treated with oral compound glycyrrhizin based on control group, both groups were treated for 1 month. The PASI scores before and after treatment, clinical effect and the incidence of adverse reactions were compared between the two groups. Results Before treatment, no significantly difference of PASI scores was found between the two groups （ P 〉 0.05 ） ; after treatment, the PASI scores of observation group was lower than control group （ P 〈 0. 05 ）. The observation group of clinical effect was better than control group （ P 〈 0. 05 ）. No statistically significant of the incidence of adverse reactions was found between the two groups （ P 〉 0.05 ）. Conclusion Compound glycyrrhizin has an exactly clincial effect in the adjuvant treatment of psoriasis vulgaris, it can effectively improve the skin lesions, and with less adverse reactions.