奥硝唑抗蠕形螨治疗丘疹脓疱型玫瑰痤疮

Anti-mites effect of ornidazole in the treatment of papulopustular rosacea

目的:对比甲硝唑、奥硝唑对丘疹脓疱型玫瑰痤疮的治疗效果,探讨通过杀灭蠕形螨治疗丘疹脓疱型玫瑰痤疮的新方法。方法:收集我科门诊2015-01~2016-03螨虫阳性的丘疹脓疱型玫瑰痤疮患者311例,随机分为甲硝唑治疗组(n=155)和奥硝唑治疗组(n=156),分别采用甲硝唑片、奥硝唑片治疗14d,并于治疗结束后随访14d。统计分析两组患者螨虫转阴率、治愈率、总有效率及复发率,对比甲硝唑与奥硝唑的治疗效果。结果:甲硝唑治疗组螨虫转阴率为72%,治愈率为63%,总有效率为81%,复发率为10%;奥硝唑治疗组螨虫转阴率为83%,治愈率为78%,总有效率为90%,复发率为7%。两组转阴率、治愈率、总有效率比较,差异有统计学意义(P<0.05);复发率比较,差异无统计学意义(P>0.05)。结论:甲硝唑、奥硝唑治疗螨虫阳性的丘疹脓疱型玫瑰痤疮均有明显疗效,奥硝唑抗蠕形螨治疗丘疹脓疱型玫瑰痤疮效果优于甲硝唑。

Objective： To compare the therapeutic effect of papulopustular rosacea with metronidazole and ornidazole, to find a better way to treat papulopustular rosacea by anti--mites.Methods： A total of 311 outpatients with papulopustular rosacea from January 2015 to March 2016 were divided into two groups, metronidazole group （n = 155） and ornidazole group （n = 156）, metronidazole group were treated with metronidazole and another with ornidazole totally 14 days,then followed up them for 14 days.The therapeutic effect of the two drugs,the negative rates, cure rates, total effective rates and recurrence rates were compared. Results：The negative rate of metronidazole group （72%） was lower than that of ornidazole group（83%） （P〈0.05）,the cure rate of metronidazole group（63%） Was significantly lower than that of ornidazole group （78%） （P 〈0.05）, and the effective rate of metronidazote group （81 %） also was lower than that of ornidazole group （90%）（P〈0.05）, but recurrence rate of metronidazole group（10%） and ornidazole group（7 % ） had no statistical differences （P 〉0.05）.Conclusion. Metronidazole and ornidazole had obvious therapeutic effect to treat papulopustular rosacea, and metronidazole was better than ornidazole in anti--mites.