乌鲁木齐某社区维吾尔族和汉族血清25-羟维生素D与糖化血红蛋白的相关性分析

Relationship between serum 25-hydroxy vitamin D level and glycated hemoglobin A,c level in Uygur and Han nationality in a community in Urumqi

1665例维吾尔族及汉族样本列入研究（维/汉：719/946;男/女：506/1159）,年龄18~82岁[维吾尔族/汉族平均年龄：（44±13）岁/（48±16）岁],分析血清25-羟维生素D水平的变化与HbA1c的相关性.并分析与民族、性别、是否患糖尿病之间的相关性.采用单因素方差分析、t检验、Pearson相关分析进行统计学分析.结果 （1）血清25-羟维生素D水平维吾尔族明显低于汉族[（13±7）比（19±8）μg/L,t=11.543,P〈0.001],女性明显低于男性[（15±9）比（18±7）μg/L,t=5.413,P〈0.001];HbA1c水平维吾尔族明显高于汉族[（6.0±1.4）%比（5.8±1.2）%,t=-2.356,P〈0.05],男女间无统计学差异（P〉0.05）.（2）在血清25-羟维生素D水平充足、缺乏及不足三组间比较HbA1c,维吾尔族男性亚组中的HbA1c差异有统计学意义（F=11.763,P〈0.001）其他人群中未见差异（P〉0.05）.（3）相关分析发现,维吾尔族男性组血清25-羟维生素D与HbA1c呈正相关（r=0.157,P〈0.05）,控制年龄后仍有相关性（r=0.228,P〈0.05）.结论 在维吾尔族男性人群中,血清25-羟维生素D水平与HbA1c呈正相关,但相关程度较小.

Objective To analyze the relationship between serum 25-hydroxy vitamin D[25（OH）D]level and glycated hemoglobin A1c（HbA1c） level in a Urumqi Uygur and Han community. Method A total of 2080 cases from a diabetes epidemiological survey conducted in a Urumqi community from May to June 2013 were used. Altogether 1665 Uygur and Han cases with complete data were included for this study（Uygur/ Han：719/946;male/female：502/1163）,with ages ranging from 18 to 82 years old, average age [Uygur/ Han：（44±13）（/ 48±16）years old]. Serum 25 （OH） D level and HbA1c concentration were measured.The correlation between 25（OH）D level and HbA1c level was analyzed. The correlation between ethnics,gender and diabetic status was analyzed. The single factor analysis of variance, t test and Pearson correlation analysis were used for statistical analysis. Results （1） The 25（OH）D level of Uygur was significantly lower than that of Han[（13＋7） vs （19±8） μg/L, t=16.543, P〈0.001]; male had significantly higher 25（OH）D level than female [（18±7） vs （16±9） μg/L, t=5.413, P〈0.001]. Uygur had greatly higher HbA1c level than Han （[ 6.0±1.4）%vs （5.8±1.2）%, t=-2.356, P=0.012], no statistical difference was found between men and women （P〉0.05）. （2） In Uygur male subjects with adequate 25 （OH） D level, lack of 25（OH）D level or insufficient 25（OH）D level, the HbA1c were different （F=11.763, P〈0.001）.（3）Correlation analysis found that in Uygur male, 25（OH）D was positively related to HbA1c level（r=0.157,P=0.029）and the difference did not change after controlling for age（r=0.228,P=0.001）. Conclusion In Uygur male subjects, the 25（OH）D level is positively correlated with HbA1c level although the correlation is small.