中青年缺血性脑血管病与高同型半胱氨酸血症的关系

Relationship between ischemic cerebrovascular disease and plasma homocysteine level in young and middle-aged patients

目的:探讨中青年缺血性脑血管病与高同型半胱氨酸血症之间的关系。方法:确诊为脑梗死的中青年患者100例为脑梗死组,短暂性脑缺血100例为脑缺血组,分别检查2组的血浆同型半胱氨酸水平,并与100例健康体检者(对照组)比较,分析高同型半胱氨酸血症与中青年缺血性脑血管病之间的关系。结果:中青年脑梗死组和脑缺血组患者的血浆同型半胱氨酸水平明显高于对照组(P<0.05),高同型半胱氨酸血症的发生率均明显高于对照组(P<0.05)。结论:高同型半胱氨酸血症与中青年缺血性脑血管病的发生存在一定关系。

Objective： To investigate the relationship between ischemic cerebrovascular disease and high plasma homocysteinemia. Methods： 100 patients with cerebral infarction were assigned into the cerebral infarction group. 100 patients with transient cerebral ischemia served as the cerebral ischemia group. Plasma homocysteine levels were measured in the cerebral infarction group and cerebral ischemia group and compared with those of 100 healthy subjects（ control group）. The relationship between hyperhomocysteinemia and young ischemic cerebrovascular disease was analyzed. Results： The plasma homocysteine level in the middle cerebral infarction group and cerebral ischemia group was significantly higher than that of control group（ P 〈 0. 05）. The incidence of hyperhomocysteinemia was significantly higher than that of control group（ P 〈0. 05）. Conclusion： Hyperhomocysteinemia and the occurrence of ischemic cerebrovascular disease in young and middle shows a certain relationship.