左旋肉碱联合有氧运动对肥胖男性精子形态及DNA损伤的影响

Effect of L-carnitine combined with aerobic exercise on sperm morphology and DNA injury of obese men

目的 研究左旋肉碱联合有氧运动对肥胖男性精子形态及DNA损伤的影响.方法 选择2014年1月至2015年12月肥胖男性不育患者90例,按照干预措施随机分成三组,A组给予口服左旋肉碱联合有氧运动;B组给予单纯口服左旋肉碱;C组给予单纯有氧运动.比较各组患者干预前后精子形态及DNA碎片率变化.结果 A、B两组干预后精子畸形率和DNA碎片率均明显低于干预前;C组干预后精子畸形率及DNA碎片率无明显变化.结论 左旋肉碱可以明显改善肥胖男性不育患者的精子形态和DNA损伤,有氧运动可以促进左旋肉碱的这一作用.

Objective To investigate the effect of L-carnitine combined with aerobic exercise on obese men.Methods From January 2014 to December 2015, 90 obese patients with infertility were randomly divided into three groups： group A was treated with L-carnitin and aerobic exercise; group B was treated with L-carnitin only; group C was treated with aerobic exercise only. The sperm morphology and DNA injury of each group before and after intervention was compared.Results After intervention, the sperm morphology and DNA injury of group A and group B were both lower than those before intervention. For group C, the sperm morphology and DNA injury didn＆#39;t change obviously.Conclusions L-carnitine can improve the sperm morphology and DNA injury of obese men obviously, and this effect can be promoted by aerobic exercise.