男性阻塞性睡眠呼吸暂停综合征患者应用持续气道正压通气治疗前后的性激素变化及临床分析

Changes sex hormones in male patients with obstructive sleep apnea syndrome after treatment of continuous positive airway pressure

目的探讨夜间持续气道正压通气(CPAP)对男性阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并性激素减退患者的疗效观察。方法测定45例男性OSAHS患者及对照组25例的血清性激素水平,包括睾酮(TT)、黄体生成素(LH)和促卵泡生成素(FSH),对男性OSAHS患者采用夜间持续CPAP治疗,分别观察治疗1个月及3个月后血清性激素水平的变化。结果 OSAHS组患者血清性激素水平明显降低,采用夜间持续CPAP治疗1个月及3个月后其血清性激素水平逐渐提高,尤以治疗3个月后为著(P<0.01);虽较对照组仍偏低,但无统计学差异(P>0.05)。结论合并有性激素减退的男性OSAHS患者应用CPAP进行治疗,可有助于性激素水平的恢复,对改善性功能减退可能有效。

Objective To investigate the effects of continuous positive airway pressure at night on sex hormone level in patients with obstructive sleep apnea hypopnea syndrome and sex hormone hypothyroidism. Methods The levels of serum sex hormones in 45 patients with obstructive sleep apnea hypopnea syndrome and 25 normal control were measured, including testosterone （TT）, luteinizing hormone （LH） and follicle stimulating hormone （FSH）. The patients with apnea hypopnea syndrome were treated with CPAP at night, and the changes of serum sex hormone levels were observed after one and three months respectively. Results The level of serum sex hormones in OSAHS patients was significantly lower than that in the control group （P〈0.01）, and the serum levels of sex hormones were significantly increased after 1 month and 3 months of treatment with CPAP. There were no statistical differences in the levels of sex hormones between control group and 3 months treatment group （P〉0.05）. Conclusion Continuous positive positive pressure at night may be great benefit to the recovery of sex hormones and improvement of sexual dysfunction in OSAHS patients with hypogonadism.