尿肌氨酸与血清PSA在前列腺癌早期诊断中的意义

Correlation analysis between urinary sarcosine and serum PSA in early diagnosis of prostate cancer

目的探讨前列腺癌(PCa)患者尿肌氨酸与血清前列腺特异性抗原(PSA)在早期诊断中的相关性。方法采用肌氨酸氧化酶法对21例PCa患者、17例良性前列腺增生症(BPH)患者和50例健康体检男性进行尿标本的肌氨酸含量检测,并比较各组间尿肌氨酸含量的差异及其与血清PSA水平、PCa病理分级的关系。结果 PCa患者的尿肌氨酸和血清PSA水平均明显高于BPH患者(P<0.05),但两者间无相关关系(r2=0.04,P>0.05)。PCa患者的Gleason评分越高,尿液中肌氨酸含量也越高(P<0.05),而与血清PSA水平无关(P>0.05)。结论随着PCa病理分级的增高,尿肌氨酸含量亦增高,检测尿液中肌氨酸含量有助于PCa的筛检和早期诊断。

Objective To analyze the correlation between urinary sarcosine and serum PSA in early diagnosis of prostate cancer. Methods The levels of urinary sarcosine in urine samples of 21 prostate cancer patients, 17 BPH patients and 50 healthy males were detected by the method of sarcosine oxidase, then the differences of urinary sarcosine content of each group and its relationship between serum PSA level as well as the pathological grading of prostate cancer were comparatively analyzed. Results The levels of urinary sarcosine and serum PSA of patients with prostate cancer were significantly higher than that of patients with BPH （P〈0.05）, but there existed no correlation （r2=0.04, P〉0.05）. The level of urinary sarosine increased as the Gleason grading of patients with PCa increased （P〈0.05）, whereas it didn＇t correlate with serum PSA level（P〉0.05）. Conclusions Urinary sarcosine content elevated with increase of pathological grading of prostate cancer, therefore urinary sarcosine content combining with serum PAS contributed to improving early diagnosis of prostate cancer.