补气活血法治疗冠心病心肌缺血气虚血瘀证临床观察

Clinical Observation of Supplementing Qi and Activating Blood Therapy for Myocardial Ischemia of Coronary Heart Disease with Qi Deficiency and Blood Stasis Syndrome

目的:观察补气活血法治疗冠心病心肌缺血气虚血瘀证的临床疗效。方法:选取60例冠心病心肌缺血气虚血瘀证患者,随机分为对照组和观察组各30例。对照组给予舒血宁注射液合硝酸异山梨酯片治疗,观察组给予补气活血法治疗。观察2组心功能的改善情况及药物安全性。结果:治疗后,2组ST段压低次数均较治疗前减少(P<0.05),ST段压低持续时间均较治疗前缩短(P<0.05);观察组ST段压低次数少于对照组(P<0.05),ST段压低持续时间短于对照组(P<0.05)。治疗后,2组心率(HR)、收缩压(SBP)及心肌耗氧量指数(RPP)均较治疗前下降(P<0.05),观察组的HR、SBP及RPP均较对照组下降更明显(P<0.05)。治疗后,2组左心室射血分数(LVEF)、左心室短轴缩短率(LVFS)和E峰与A峰比值(E/A)均较治疗前改善(P<0.05),观察组LVEF、LVFS及E/A的改善情况均优于对照组(P<0.05)。观察组药物不良反应发生率10.00%,低于对照组的30.00%(P<0.05)。结论:补气活血法治疗冠心病心肌缺血气虚血瘀证,临床疗效显著,能有效改善患者的心功能,用药安全性高。

Objective： To observe the clinical effect of supplementing qi and activating blood therapy for myocardial ischemia of coronary heart disease with qi deficiency and blood stasis syndrome. Methods ：Selected 60 cases of patients with myocardial ischemia of coronary heart disease with qi deficiency and blood stasis syndrome,and divided them into the control group and the observation group randomly,30 cases in each group. The control group was treated with Shuxuening injection and isosorbide dinitrate tablets,while the observation group was treated with supplementing qi and activating blood therapy.Observed the improvements of heart function and drug safety in both groups. Results：After treatment,comparing with those before treatment,the frequency of ST segment depression in both groups was decreased（P〈0.05）,and the duration of ST segment depression was shortened（P〈0.05）. The frequency of ST segment depression in the observation group was less than that in the control group,and the duration of ST segment depression in the observation group was shorter than that in the control group（P〈0.05）. After treatment,heart rate（HR）,systolic blood pressure（SBP） and rate pressure product（RPP） in both groups were all declined when compared with those before treatment（P〈0.05）,and the decrease of HR,SBP and RPP in the observation group was more obvious than that in the control group（P〈0.05）. After treatment,comparing with those before treatment,left ventricular ejection fraction（LVEF）,left ventricularfractional shortening（LVFS） rate and the ratio of peak E and A（E/A） in both groups were all improved（P〈0.05）,and the improvements of LVEF,LVFS and E/A in the observation group were superior to those in the control group（P〈0.05）. The incidence of drug adverse reaction rate was 30.00% in the control group,being higher than 10.00% in the observation group（P〈0.05）. Conclusion：The supplementing qi and activating blood therapy for myocardial ischemia of coronary heart disease with qi deficiency and blood stasis syndrome has significant curative effect.It can effectively improve heart function of patients and has high safety.